ArticleMikrochimica acta2021
Dual-enhancement and dual-tag design for SERS-based sandwich immunoassays: evaluation of a metal-metal effect in 3D architecture.
Article in Mikrochimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Gold- or Silver-Nanoparticle SERS Platforms for Plasma-Based Diagnostics and AI-Driven Analysis.Sensors (Basel, Switzerland) · 2026Review
- Recent advances of Au@Ag core-shell SERS-based biosensors.Exploration (Beijing, China) · 2023Review
- Development of SERS-based immunoassay for the detection of cryptococcosis biomarker.Analytical and bioanalytical chemistry · 2022Article
- Recent Advances in Sandwich SERS Immunosensors for Cancer Detection.International journal of molecular sciences · 2022Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The design of a sandwich-type SERS immunoassay (surface-enhanced Raman spectroscopy) is demonstrated operating in dual surface enhancement and dual-tag paradigm. The capture and detection antibodies are linked to two SERS-active substrates and form together the three-dimensional (3D) structure after specific binding to interleukin 6. A variety of metal combinations is tested (Au-Ag, Au-Au, and Ag-Ag), but an enhanced electromagnetic field is generated only due to coupling of Ag and Au nanoparticles with an Au hexagonal nanoarray. The amplified in that way Raman signals improve the limit of detection over 3 times in comparison to the assay with only one SERS-active substrate. It is also shown that the proper readout of the true-positive signal can be achieved in assays with two Raman tags, and this approach also improves LOD. For the optimal combination of the metal-metal junction and Raman tags, a linear relationship between the Raman signal and the concentration of IL-6 is obtained in the range 0-1000 pg⋅mL
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