Evidence map›Paper›PMID 34931940›Full record

ArticleEmerging microbes & infections2022

Generation and characterization of genetically and antigenically diverse infectious clones of dengue virus serotypes 1-4.

Tomokazu Tamura, Jiayu Zhang, Vrinda Madan, Abhishek Biswas, Michael P Schwoerer, Thomas R Cafiero, Brigitte L Heller, Wei Wang, Alexander Ploss

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Dengue Dilemma: Navigating Cross-Reactivity and Immune Challenges.Current topics in microbiology and immunology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. TheProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tomokazu TamuraDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Jiayu ZhangDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Vrinda MadanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Abhishek BiswasDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Michael P SchwoererDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Thomas R CafieroDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Brigitte L HellerDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Wei WangCarl Icahn Laboratory, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
Alexander PlossDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.
Princeton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Rational design and efficacy testing of vaccines against HCVR01AI168048 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Alexander Andrianov, Thomas R Fuerst · 2022 to 2026
$7.1M
Genetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0M
Modeling immune impairments and pathogenesis in novel humanized mice for HBV-HIV co-infectionR01AI138797 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PLOSS, ALEXANDER, SU, LISHAN · 2018 to 2022
$3.9M
Data-Driven Mathematical and Computational Modeling of Hepatitis D Infection and Treatment ResponseR01AI146917 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI DAHARI, HAREL · 2020 to 2024
$3.5M
Mechanisms of hepatitis B virus cccDNA formationR01AI153236 · NIAID · PRINCETON UNIVERSITY · PI PLOSS, ALEXANDER · 2020 to 2024
$2.8M
NIAID NIH HHS R01 AI107301NIAID NIH HHS R01 AI138797NIAID NIH HHS R01 AI146917NIAID NIH HHS R01 AI153236NIAID NIH HHS R01 AI168048NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Dengue is caused by four genetically distinct viral serotypes, dengue virus (DENV) 1-4. Following transmission by

Indexed as

AedesAnimalsAntibodies, ViralAntigenic VariationDengueDengue VirusGenetic VariationHumansImmunoglobulin MMiceMice, KnockoutReverse GeneticsSerogroupAntibodies, ViralImmunoglobulin Manimal modelsDenguedengue virushost responsehost tropism

Identifiers

PMID34931940
PMCPMC8745371
OpenAlexW4200486608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.