Evidence map›Paper›PMID 34931883›Full record

ArticlemSystems2021

Ancient Metagenomic Studies: Considerations for the Wider Scientific Community.

Clio Der Sarkissian, Irina M Velsko, Anna K Fotakis, Åshild J Vågene, Alexander Hübner, James A Fellows Yates

Abstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Clio Der Sarkissian *Centre for Anthropobiology and Genomics of Toulouse, UMR5288, CNRS, University Toulouse 3 Paul Sabatier, Toulouse, France.ORCID 0000-0003-4312-9085
Irina M Velsko *Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0001-9810-9917
Anna K Fotakis *Center for Evolutionary Hologenomics, GLOBE Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4585-4662
Åshild J Vågene *Section for Evolutionary Genomics, GLOBE Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7478-8297
Alexander Hübner *Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0003-3572-9996
James A Fellows Yates *Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.ORCID 0000-0001-5585-6277

Funding

Carlsbergfondet (Carlsberg Foundation) CF18-1109Centre National de la Recherche Scientifique (CNRS)Danmarks Grundforskningsfond (DNRF) CEH - DNRF143Deutsche Forschungsgemeinschaft (DFG) 390713860EC | H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC) ERC-2015-StG 678901-FoodTransformsMax-Planck-Gesellschaft (MPG)Werner Siemens-Stiftung Paleobiotechnology
6 · The paper itself

Abstract

Like modern metagenomics, ancient metagenomics is a highly data-rich discipline, with the added challenge that the DNA of interest is degraded and, depending on the sample type, in low abundance. This requires the application of specialized measures during molecular experiments and computational analyses. Furthermore, researchers often work with finite sample sizes, which impedes optimal experimental design and control of confounding factors, and with ethically sensitive samples necessitating the consideration of additional guidelines. In September 2020, early career researchers in the field of ancient metagenomics met (Standards, Precautions & Advances in Ancient Metagenomics 2 [SPAAM2] community meeting) to discuss the state of the field and how to address current challenges. Here, in an effort to bridge the gap between ancient and modern metagenomics, we highlight and reflect upon some common misconceptions, provide a brief overview of the challenges in our field, and point toward useful resources for potential reviewers and newcomers to the field.

Indexed as

ancient DNAancient metagenomicsarchaeogenomicsarchaeologyauthenticationcultural heritageethicsmetagenomicsmicrobemicrobiomepaleogeneticspeer review

Identifiers

PMID34931883
PMCPMC8691190

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.