Observational studyRadiology2022
Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at
Open access · greenAbstract readObservational Study
In one paragraph
Observational study in Radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review.Respiratory research · 2026Pooled it
- Review of quantitative and functional lung imaging evidence of vaping-related lung injury.Frontiers in medicine · 2024Pooled it
- Review
- Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials.American journal of respiratory and critical care medicine · 2026Review
- Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Characterizing chronic obstructive pulmonary disease using quantitative MRI biomarkers.The British journal of radiology · 2026Review
- 3D CT-Based quantification of airway structural changes during asthma exacerbations: a retrospective observational study.BMC pulmonary medicine · 2026Observational
- Mucus Plugging as a Treatable Trait Across the Asthma-COPD Spectrum: The Role of Type 2 Cytokine Blockade and Quantitative Imaging.Biomedicines · 2026Review
- Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026Article
- Simulation-Driven Annotation-Free Deep Learning for Automated Detection and Segmentation of Airway Mucus Plugs on Non-Contrast CT Images.Bioengineering (Basel, Switzerland) · 2026Article
- Tezepelumab in severe asthma: chest computed tomography assessment of airway remodeling and clinical remission.Frontiers in pharmacology · 2026Article
- Back to the future in asthma imaging: quantitative assessment and new perspectives.La Radiologia medica · 2026Review
- Multidisciplinary Recommendations for the Use of Chest CT and Bronchial Biopsy in Severe Asthma: An Expert Consensus Based on Real-World Experience.Journal of asthma and allergy · 2026Article
- Clinical and pathophysiological roles of lower lobe-dominant mucus plugs on computed tomography in patients with asthma with and without bronchiectasis.The journal of allergy and clinical immunology. Global · 2025Article
- A deep learning-based automated detection of mucus plugs in chest computed tomography.ERJ open research · 2025Article
- Ventilation defect burden predicts lung cancer resection outcomes.ERJ open research · 2025Article
- Mucins and Their Roles in Asthma.Immunological reviews · 2025Review
- Computed tomography characteristics of chronic bronchitis and its association with disease severity and clinical outcomes in viral pneumonia: a retrospective cohort study.Journal of thoracic disease · 2025Article
- FeFrontiers in physiology · 2025Article
- Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction.ERJ open research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
David G MummyFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0001-7885-109X
Eleanor M DunicanFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
Katherine J CareyFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
Michael D EvansFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0001-7449-3993
Brett M ElickerFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0001-6188-9622
John D NewellFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0002-7337-5001
David S GieradaFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0002-9102-4475
Scott K NagleFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0002-0770-708X
Mark L SchieblerFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0002-9120-5428
Ronald L SorknessFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
Nizar N JarjourFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0003-0170-8927
Loren C DenlingerFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
John V FahyFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).
Sean B FainFrom the Center for In Vivo Microscopy and Department of Radiology, Duke University, Durham, NC (D.G.M.); School of Medicine, University College Dublin, Dublin, Ireland (E.M.D.); Departments of Medical Physics (K.J.C., S.K.N., S.B.F.), Biostatistics and Medical Informatics (M.D.E.), Radiology (S.K.N., M.L.S., S.B.F.), Pharmacy (R.L.S.), Pediatrics (S.K.N., R.L.S.), and Allergy, Pulmonary & Critical Care Medicine (R.L.S., N.N.J., L.C.D.), Wisconsin Institutes for Medical Research, University of Wisconsin-Madison, 1111 Highland Ave, Room 2488, Madison, WI 53705; Department of Radiology (B.M.E.) and School of Medicine (J.V.F.), University of California-San Francisco, San Francisco, Calif; Department of Radiology, University of Iowa, Iowa City, Iowa (J.D.N., S.B.F.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (D.S.G.).ORCID 0000-0001-5461-0646
University of Wisconsin–Madison · USUniversity of California, San Francisco · USUniversity of Iowa · USMallinckrodt (United States) · USUniversity College Dublin · IE
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3MProtein carbohydrate interactions in the pathophysiology of asthma exacerbationsR01HL080414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John V Fahy · 2005 to 2026
$9.2MStability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9MViral Induced Asthma ExacerbationsR01HL080412 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2005 to 2009
$2.0MXeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung DiseaseS10OD016394 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI FAIN, SEAN BEDILION · 2013 to 2013
$600kNHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL080412NHLBI NIH HHS R01 HL080414NHLBI NIH HHS U10 HL109168NIAID NIH HHS U19 AI077439NIH HHS S10 OD016394
Abstract
Background Airway mucus plugs in asthma are associated with exacerbation frequency, increased eosinophilia, and reduced lung function. The relationship between mucus plugs and spatially overlapping ventilation abnormalities observed at hyperpolarized gas MRI has not been assessed quantitatively. Purpose To assess regional associations between CT mucus plugs scored by individual bronchopulmonary segment and corresponding measurements of segmental ventilation defect percentage (VDP) at hyperpolarized helium 3 (
Indexed as
AsthmaRespiration DisordersFemaleHeliumHumansLungMagnetic Resonance ImagingMaleMucusTomography, X-Ray ComputedHelium
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