ArticleThe Plant cell2022
The two clock proteins CCA1 and LHY activate VIN3 transcription during vernalization through the vernalization-responsive cis-element.
Article in The Plant cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
- CCRG1 Acts as a Downstream Effector of the Clock Proteins CCA1 and LHY to Coordinate Growth, Flowering, and Senescence.Plant, cell & environment · 2026Article
- Arabidopsis Circadian Clock Protein CCA1 Negatively Regulates the Calcium-Binding Protein CCaP1 to Modulate Dark-Responsive Stomatal Movement.Plant, cell & environment · 2026Article
- Article
- RrLHY regulates arginine biosynthesis by activating RrNAGS1 in Rosa roxburghii fruit.Plant cell reports · 2026Article
- Conserved gene- and network-level thermal memory intervals in two divergent perennial crucifers in nature.PloS one · 2026Article
- Potential regulatory modules to integrate microgravity signals into flowering pathways in Arabidopsis thaliana grown in space.NPJ microgravity · 2025Article
- Seasons and shape: inflorescences from autumn to summer.Journal of experimental botany · 2025Review
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- Article
- Unraveling the signaling pathways of plant cold stress: current insights and future directions.Frontiers in plant science · 2025Review
- The overexpression of the switchgrass (Panicum virgatum L.) genes PvTOC1-N or PvLHY-K affects circadian rhythm and hormone metabolism in transgenic Arabidopsis seedlings.Biotechnology for biofuels and bioproducts · 2024Article
- C-TERMINAL DOMAIN PHOSPHATASE-LIKE 1 promotes flowering with TAF15b by repressing the floral repressor gene FLOWERING LOCUS C.Molecules and cells · 2024Article
- CIRCADIAN CLOCK-ASSOCIATED1 Delays Flowering by Directly Inhibiting the Transcription ofPlants (Basel, Switzerland) · 2024Article
- Vernalization promotes bolting in sugar beet by inhibiting the transcriptional repressors of BvGI.Plant molecular biology · 2024Article
- A MYB-related transcription factor ZmMYBR29 is involved in grain filling.BMC plant biology · 2024Article
- Circadian clock factors regulate the first condensation reaction of fatty acid synthesis in Arabidopsis.Cell reports · 2023Article
- Characteristics and Functions of MYB (v-Myb avivan myoblastsis virus oncogene homolog)-Related Genes inGenes · 2023Review
- Epigenetic silencing of callose synthase by VIL1 promotes bud-growth transition in lily bulbs.Nature plants · 2023Article
- Identification of the inducible activity in the promoter of the soybeanPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- A chromosome-level genome assembly of radish (Raphanus sativus L.) reveals insights into genome adaptation and differential bolting regulation.Plant biotechnology journal · 2023Article
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10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vernalization, a long-term cold-mediated acquisition of flowering competence, is critically regulated by VERNALIZATION INSENSITIVE 3 (VIN3), a gene induced by vernalization in Arabidopsis. Although the function of VIN3 has been extensively studied, how VIN3 expression itself is upregulated by long-term cold is not well understood. In this study, we identified a vernalization-responsive cis-element in the VIN3 promoter, VREVIN3, composed of a G-box and an evening element (EE). Mutations in either the G-box or the EE prevented VIN3 expression from being fully induced upon vernalization, leading to defects in the vernalization response. We determined that the core clock proteins CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1) and LATE-ELONGATED HYPOCOTYL (LHY) associate with the EE of VREVIN3, both in vitro and in vivo. In a cca1 lhy double mutant background harboring a functional FRIGIDA allele, long-term cold-mediated VIN3 induction and acceleration of flowering were impaired, especially under mild cold conditions such as at 12°C. During prolonged cold exposure, oscillations of CCA1/LHY transcripts were altered, while CCA1 abundance increased at dusk, coinciding with the diurnal peak of VIN3 transcripts. We propose that modulation of the clock proteins CCA1 and LHY participates in the systems involved in sensing long-term cold for the activation of VIN3 transcription.
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