Evidence map›Paper›PMID 34931603›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2022

Socioeconomic status impacts blood pressure response to positive airway pressure treatment.

Ikuyo Imayama, Ahana Gupta, Pei-Shan Yen, Yi-Fan Chen, Brendan Keenan, Raymond R Townsend, Julio A Chirinos, Frances M Weaver, David W Carley, Samuel T Kuna and 1 more

2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01578031 nacompletednot on this map

Responses to CPAP Treatment in Obese and Lean Sleep Apnea Patients

TypeinterventionalSponsorUniversity of PennsylvaniaRan2009 to 2014Enrolled450ConditionsSleep Apnea, ObesityArmsPositive Airway Pressure During Sleep (ResMed S9 Elite), Usual Care
NCT01960465 nacompletednot on this map

Targeted Treatment of Obstructive Sleep Apnea to Reduce Cardiovascular Disparity

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2015 to 2019Enrolled220ConditionsSleep Apnea SyndromesArmsContinuous positive airway pressure
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ikuyo ImayamaDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Ahana GuptaGPPA Medical Scholars Program, University of Illinois at Chicago, Chicago, Illinois.
Pei-Shan YenDivision of Epidemiology & Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois.
Yi-Fan ChenBiostatistics Core, Center for Clinical and Translational Science, University of Illinois at Chicago, Chicago, Illinois.
Brendan KeenanDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Raymond R TownsendDivision of Nephrology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Julio A ChirinosDivision of Cardiology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Frances M WeaverCenter of Innovation for Complex Chronic Health Care (CINCCH), Hines VA, Hines, Illinois.
David W CarleyDepartment of Biobehavioral Health Science, University of Illinois at Chicago, Chicago, Illinois.
Samuel T KunaDivision of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Bharati PrasadDivision of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
University of Illinois Chicago · USUniversity of Pennsylvania · USEdward Hines, Jr. VA Hospital · USJesse Brown VA Medical Center · USPhiladelphia VA Medical Center · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Understanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7M
NCATS NIH HHS UL1 TR002003NHLBI NIH HHS P01 HL094307
6 · The paper itself

Abstract

STUDY

objectivesPositive airway pressure (PAP) treatment of obstructive sleep apnea reduces blood pressure (BP). Retrospective data suggest that African Americans (AA), a group at high-risk for hypertensive organ dysfunction, may have a greater BP response to PAP therapy than European Americans (EA). We examined the difference in 24-hour BP response to 3 months of PAP treatment between AA and EA.

methodsParticipants (n = 259, 161 AA and 98 EA) with apnea-hypopnea index ≥ 15 events/h from 2 prospective cohorts were included.

resultsParticipants were middle aged (mean ± SD, 53.8 ± 9.3 years), 86% (227) men, apnea-hypopnea index 35.6 ± 19.2 events/h, and PAP adherence of 3.36 ± 2.24 h/day. The reductions in 24-hour systolic and diastolic BP (mm Hg) were not different in AA vs EA (systolic = -1.13 ± 12.1 vs -0.61 ± 12.8,

conclusionsTwenty-four hour BP response to PAP treatment is similar in AA and EA. Adherence to PAP treatment is more effective in improving 24-hour systolic BP in those with low SES. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Name: Race and CPAP Effectiveness (RACE); URL: https://clinicaltrials.gov/ct2/show/NCT01960465; Identifier: NCT01960465 and Registry: ClinicalTrials.gov; Name: The Effects of Treating Obese and Lean Patients with Sleep Apnea (PISA); URL: https://clinicaltrials.gov/ct2/show/NCT01578031; Identifier: NCT01578031. CITATION: Imayama I, Gupta A, Yen PS, et al. Socioeconomic status impacts blood pressure response to positive airway pressure treatment.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveBlood PressureFemaleHumansMaleMiddle AgedProspective StudiesRetrospective StudiesSocial Classhypertensionobstructive sleep apnea (OSA)positive airway pressure (PAP)racesocioeconomic status

Identifiers

PMID34931603
PMCPMC9059597
OpenAlexW4200573998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.