Evidence map›Paper›PMID 34931476›Full record

ArticleThoracic cancer2022

Dramatic response to immunochemotherapy followed by salvage surgery in an elderly lung cancer patient.

Yoshio Okano, Michihiro Kunishige, Yoshihiro Kondo, Naoki Kadota, Atsushi Morishita, Keishi Naruse, Hisanori Machida, Nobuo Hatakeyama, Hiroyuki Hino, Tsutomu Shinohara and 2 more

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In one paragraph

Article in Thoracic cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yoshio OkanoDepartment of Respiratory Medicine, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Michihiro KunishigeDepartment of Respiratory Medicine, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Yoshihiro KondoDepartment of Respiratory Medicine, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Naoki KadotaDepartment of Respiratory Medicine, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Atsushi MorishitaDepartment of Thoracic Surgery, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Keishi NaruseDepartment of Pathology, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Hisanori MachidaDepartment of Respiratory Medicine, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Nobuo HatakeyamaDepartment of Respiratory Medicine, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Hiroyuki HinoDepartment of Thoracic Surgery, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Tsutomu ShinoharaDepartment of Community Medicine for Respirology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Shoji SakiyamaDepartment of Thoracic Surgery, National Hospital Organization Kochi Hospital, Kochi City, Japan.
Eiji TakeuchiDepartment of Clinical Investigation, National Hospital Organization Kochi Hospital, Kochi City, Japan.ORCID 0000-0003-1541-9747
National Hospital Organization Kochi National Hospital · JPTokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) have caused a paradigm shift in the treatment of lung cancer. Here, we encountered a case of inoperable locally advanced squamous cell carcinoma of the lung that became operable with pembrolizumab-based immunochemotherapy and achieved a pathological complete response. An 82-year-old man suspected of having lung cancer was referred to our hospital. The patient was clinically diagnosed with left upper lobe squamous cell carcinoma cT2aN3M0 c-stage IIIC. Immunostaining revealed the expression of programmed death-ligand 1 in 60% of tumor cells. The cancer cells disappeared after two cycles of chemotherapy with carboplatin and nanoparticle albumin-bound paclitaxel plus pembrolizumab. As the abnormal accumulation of

Indexed as

Carcinoma, Non-Small-Cell LungCarcinoma, Squamous CellLung NeoplasmsAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCarboplatinHumansMaleSalvage TherapyCarboplatinadvanced squamous cell carcinoma of the lungimmune checkpoint inhibitorinduction immunochemotherapypathological complete response

Identifiers

PMID34931476
PMCPMC8807244
OpenAlexW4200067850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.