ArticleEuropean journal of heart failure2022
High selenium levels associate with reduced risk of mortality and new-onset heart failure: data from PREVEND.
Article in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.Redox biology · 2025Pooled it
- Serum Selenium Levels and Lipid Profile: A Systematic Review and Meta-analysis of Observational Studies.Biological trace element research · 2025Pooled it
- Sodium Selenite Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension by Upregulating GPX3 and Ameliorating Vascular Remodeling.Physiological research · 2026Article
- Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Exploring optimal serum selenium range for heart failure prevention: A U-shaped association and mediation by hepatic steatosis in US adults.The Journal of international medical research · 2025Article
- Low blood levels of selenium, selenoprotein P and GPx3 are associated with accelerated biological aging: results from the Berlin Aging Study II (BASE-II).Clinical epigenetics · 2025Article
- Role of selenium in the pathophysiology of cardiorenal anaemia syndrome.ESC heart failure · 2025Review
- Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Observational
- Legal Standards for Selenium Enriched Foods and Agricultural Products: Domestic and International Perspectives.Nutrients · 2024Review
- Influence of smoking status on the relationship between serum selenium and cause-specific mortality in US adults.Scientific reports · 2024Article
- Assessment of EMR ML Mining Methods for Measuring Association between Metal Mixture and Mortality for Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth.International journal of molecular sciences · 2024Review
- Metal mixture exposures and serum lipid levels in childhood: the Rhea mother-child cohort in Greece.Journal of exposure science & environmental epidemiology · 2024Article
- Diet-related inflammation is positively associated with atherogenic indices.Scientific reports · 2024Observational
- Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients.ESC heart failure · 2024Article
- Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.European journal of epidemiology · 2024Article
- Contaminant Metals and Cardiovascular Health.Journal of cardiovascular development and disease · 2023Review
- Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease.Cardiovascular diabetology · 2023Article
- Cuproptosis, the novel therapeutic mechanism for heart failure: a narrative review.Cardiovascular diagnosis and therapy · 2022Review
- Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo elucidate the relationship between serum selenium levels and the risk of mortality and new-onset heart failure (HF) in the general adult population. METHODS AND
resultsSelenium was measured in a Dutch cohort and a retrospective analysis of prospectively assessed data was performed. Main outcome measures were all-cause mortality and incidence of new-onset HF separately, and combined as a composite endpoint. Serum selenium was measured in 5973 subjects and mean selenium concentration was 84.6 (±19.5) µg/L. Mean age was 53.6 (±12.1) years and 3103 subjects (52%) were female. Median follow-up was 8.4 years. Selenium levels associated positively with female sex, higher total cholesterol and glucose concentrations, and associated negatively with incidence of anaemia, iron deficiency, current smoking, increased C-reactive protein levels, and higher body mass index. Univariate analysis on all subjects showed no association of continuous selenium concentrations, per 10 µg/L increase, with the composite endpoint (hazard ratio [HR] 0.96, 95% confidence interval [CI] 0.87-1.06, p = 0.407). However, significant interaction with smoking status was observed. In non-smoking subjects (n = 4288), continuous selenium concentrations were independently associated with reduced mortality risk (HR 0.87, 95% CI 0.79-0.96, p = 0.005), lower risk of new-onset HF (HR 0.82, 95% CI 0.69-0.96, p = 0.017), as well as reduced risk of the composite endpoint (HR 0.86, 95% CI 0.79-0.94, p = 0.001). In smoking subjects, no associations were found.
conclusionSerum selenium was independently associated with multiple indicators of the metabolic syndrome. In addition, high selenium levels were independently associated with reduced mortality and new-onset HF in non-smokers. Well-powered interventional studies are necessary to evaluate the potential benefit of repleting selenium, especially in non-smoking subjects.
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