Evidence map›Paper›PMID 34931322›Full record

ArticlePhotochemistry and photobiology2022

Ultraviolet B Irradiation Alters the Level and miR Contents of Exosomes Released by Keratinocytes in Diabetic Condition.

Jinju Wang, Kartheek Pothana, Shuzhen Chen, Harshal Sawant, Jeffrey B Travers, Ji Bihl, Yanfang Chen

Open access · hybridAbstract read
In one paragraph

Article in Photochemistry and photobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Ghrelin induced by ultraviolet B exposure promotes the restoration of diabetic cutaneous wound healing.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  5. Review
  6. Article
  7. Extracellular Vesicles: A New Star for Gene Drug Delivery.International journal of nanomedicine · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Cutaneous changes in diabetic patients: Primed for aberrant healing?Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jinju WangDepartment of Biomedical Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA.ORCID 0000-0003-1210-7676
Kartheek PothanaDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
Shuzhen ChenDepartment of Biomedical Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Harshal SawantDepartment of Biomedical Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Jeffrey B TraversDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.ORCID 0000-0001-7232-1039
Ji BihlDepartment of Biomedical Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Yanfang ChenDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA.
Marshall University · USWright State University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
Platelet Activating Factor and Epidermic CytotoxicityR01HL062996 · NHLBI · WRIGHT STATE UNIVERSITY · PI TRAVERS, JEFFREY B. · 1999 to 2023
$7.2M
UVB radiation-generated microvesicle particles as effectors for photosensitivityR01ES031087 · NIEHS · WRIGHT STATE UNIVERSITY · PI KEMP, MICHAEL GEORGE, TRAVERS, JEFFREY B. · 2021 to 2025
$1.7M
Microvesicles as a Novel Transmitter for UVB-Induced Bioactive ProductsR21AR071110 · NIAMS · WRIGHT STATE UNIVERSITY · PI BIHL, JI CHEN · 2017 to 2018
$358k
Oxidized Lipids and UV ImmunosuppressionI01BX000853 · VA · RLR VA MEDICAL CENTER · PI Jeffrey B. Travers · 2011 to 2026
–
BLRD VA I01 BX000853NHLBI NIH HHS R01 HL062996NIAMS NIH HHS R21 AR071110NIEHS NIH HHS R01 ES031087NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Ultraviolet B (UVB) stimulates the generation of extracellular vesicles, which elicit systemic effects. Here, we studied whether UVB affects the release and microRNA (miR) content of keratinocyte exosomes (EXs) in diabetic conditions. In vitro, we examined the UVB effects on affecting EX release from keratinocyte HaCaT cells (HaCaT-EX) pretreated with high glucose. HaCaT-EX functions were evaluated on Schwann cells (SCs). In vivo, UVB-induced miR change in skin EXs of diabetic db/db mice was analyzed. The miRs of interest were validated in HaCaT-EXs. We found that: (1) UVB promoted HaCaT-EX generation in dose- and time-dependent manners; 100 and 1800 J m

Indexed as

Diabetes MellitusExosomesKeratinocytesMicroRNAsAnimalsCell LineCell SurvivalGlucoseHaCaT CellsHumansMiceUltraviolet RaysGlucoseMicroRNAs

Identifiers

PMID34931322
PMCPMC9511213
OpenAlexW4200468061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.