Evidence map›Paper›PMID 34931281›Full record

ArticleNeurocritical care2022

Risk Factors for Opioid Utilization in Patients with Intracerebral Hemorrhage.

Nelson Lin, Daniel Mandel, Carlin C Chuck, Roshini Kalagara, Savannah R Doelfel, Helen Zhou, Hari Dandapani, Leana N Mahmoud, Christoph Stretz, Brian Mac Grory and 5 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Nelson LinDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Daniel MandelDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Carlin C ChuckDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Roshini KalagaraIcahn School of Medicine at Mount Sinai, New York City, NY, USA.
Savannah R DoelfelDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Helen ZhouDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Hari DandapaniDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Leana N MahmoudDepartment of Pharmacy, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Brown University, 593 Eddy St, APC 712, Providence, RI, USA.
Christoph StretzDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Brian Mac GroryDepartment of Neurology, Duke University School of Medicine, Duke University, Durham, NC, USA.
Linda C WendellDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Bradford B ThompsonDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Karen L FurieDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Ali MahtaDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA.
Michael E ReznikDepartment of Neurology, Warren Alpert Medical School of Brown University, Brown University, Providence, RI, USA. michael_reznik@brown.edu.ORCID 0000-0002-9251-5049
Brown University · USDuke University · USIcahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeadache is a common presenting symptom of intracerebral hemorrhage (ICH) and often necessitates treatment with opioid medications. However, opioid prescribing patterns in patients with ICH are not well described. We aimed to characterize the prevalence and risk factors for short and longer-term opioid use in patients with ICH.

methodsWe conducted a retrospective cohort study using data from a single-center registry of patients with nontraumatic ICH. This registry included data on demographics, ICH-related characteristics, and premorbid, inpatient, and postdischarge medications. After excluding patients who died or received end-of-life care, we used multivariable regression models adjusted for premorbid opioid use to determine demographic and ICH-related risk factors for inpatient and postdischarge opioid use.

resultsOf 468 patients with ICH in our cohort, 15% (n = 70) had premorbid opioid use, 53% (n = 248) received opioids during hospitalization, and 12% (n = 53) were prescribed opioids at discharge. The most commonly used opioids during hospitalization were fentanyl (38%), oxycodone (30%), morphine (26%), and hydromorphone (7%). Patients who received opioids during hospitalization were younger (univariate: median [interquartile range] 64 [53.5-74] vs. 76 [67-83] years, p < 0.001; multivariable: odds ratio [OR] 0.96 per year, 95% confidence interval [CI] 0.94-0.98) and had larger ICH volumes (univariate: median [interquartile range] 10.1 [2.1-28.6] vs. 2.7 [0.8-9.9] cm

conclusionsInpatient opioid use in patients with ICH is common, with some risk factors that may be mechanistically connected to primary headache pathophysiology. However, the lower frequency of opioid prescriptions at discharge suggests that inpatient opioid use does not necessarily lead to a high rate of long-term opioid dependence in patients with ICH.

Indexed as

AftercareAnalgesics, OpioidCerebral HemorrhageHeadacheHumansPatient DischargePostoperative PainPractice Patterns, Physicians'Retrospective StudiesRisk FactorsAnalgesics, OpioidOpioid analgesicsRisk factorsStroke (intracerebral hemorrhage)

Identifiers

PMID34931281
OpenAlexW4200027360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.