Evidence map›Paper›PMID 34931280›Full record

ArticleInternational journal of colorectal disease2022

Preoperative intravenous iron treatment reduces postoperative complications and postoperative anemia in preoperatively anemic patients with colon carcinoma.

Mikael Kangaspunta, Jorma Mäkijärvi, Selja Koskensalo, Arto Kokkola, Perttu Arkkila, Tom Scheinin, Suvi Rasilainen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mikael KangaspuntaFaculty of Medicine, University of Helsinki, Helsinki, Finland. mikael.kangaspunta@helsinki.fi.ORCID http://orcid.org/0000-0002-9494-1121
Jorma MäkijärviDepartment of GI Surgery, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Selja KoskensaloDepartment of GI Surgery, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Arto KokkolaDepartment of GI Surgery, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Perttu ArkkilaDepartment of Gastroenterology, Abdominal Centre, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Tom ScheininDepartment of GI Surgery, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Suvi RasilainenDepartment of GI Surgery, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnemia is common among patients with colorectal cancer and is associated with an increased risk of complications and poorer survival rate. The main objective of our study was to determine the effect of preoperative intravenous iron supplementation therapy on the need for red blood cell transfusions, other postoperative complications, and length of hospital stay in colon cancer patients undergoing colon resection.

methodsIn this retrospective cohort study, data were collected from medical records of all 549 colon carcinoma patients who underwent a colon resection in Helsinki University Hospital during the years 2017 and 2018. The patients were divided into two cohorts: one with anemic patients treated with preoperative intravenous iron supplementation therapy (180 patients) and one with anemic patients without preoperative intravenous iron supplementation therapy (138 patients). Non-anemic patients and patients requiring emergency surgery were excluded (231 patients).

resultsPatients treated with intravenous iron had less postoperative complications (33.9% vs. 45.9%, p = 0.045) and a lower prevalence of anemia at 1 month after surgery (38.7% vs. 65.3%, p < 0.01) when compared with patients without preoperative iv iron treatment. No difference was found in the amount of red blood cell transfusions, length of stay, or mortality between the groups.

conclusionThis is the first study demonstrating a significant decrease in postoperative complications in anemic colon cancer patients receiving preoperative intravenous iron supplementation therapy. This treatment also diminishes the rate of postoperative anemia, which is often associated with a facilitated recovery.

Indexed as

AnemiaCarcinomaColonic NeoplasmsHemoglobinsHumansIronPostoperative ComplicationsPreoperative CareRetrospective StudiesHemoglobinsIronAnemiaColon cancerColorectal surgeryIntravenous iron

Identifiers

PMID34931280
PMCPMC8803765
OpenAlexW4200344833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.