ArticleBrain structure & function2022
Receptor architecture of macaque and human early visual areas: not equal, but comparable.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Receptor architecture shapes the regional organization of the macaque cingulate cortex.Brain structure & function · 2026Article
- Nicotine causes highly localized and tuned changes in thalamocortical gain that cascade strongly and selectively through the cortical circuit.bioRxiv : the preprint server for biology · 2026Article
- Visual Simulation Is Supported by Sequential Monitoring in the Lateral Prefrontal Cortex.Journal of cognitive neuroscience · 2026Article
- Receptor architecture of the macaque lateral geniculate nucleus.Brain structure & function · 2026Article
- Hominoid-specific calretinin-immunopositivity of the optic radiation (geniculocalcarine tract).Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- The synaptic organization of the human temporal lobe neocortex by high-resolution transmission, focused ion beam scanning, and electron microscopic tomography.Anatomical science international · 2025Review
- Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17.Brain structure & function · 2024Article
- Generative Modelling of Cortical Receptor Distributions from Cytoarchitectonic Images in the Macaque Brain.Neuroinformatics · 2024Article
- MEBRAINS 1.0: A new population-based macaque atlas.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe.eLife · 2023Article
- Gradients of neurotransmitter receptor expression in the macaque cortex.Nature neuroscience · 2023Article
- Connectivity reveals homology between the visual systems of the human and macaque brains.Frontiers in neuroscience · 2023Article
- The pale spear-nosed bat: A neuromolecular and transgenic model for vocal learning.Annals of the New York Academy of Sciences · 2022Article
- Mutual influence between language and perception in multi-agent communication games.PLoS computational biology · 2022Article
- Understanding structure-function relationships in the mammalian visual system: part two.Brain structure & function · 2022Article
- Asymmetry of brain structure and function: 40 years after Sperry's Nobel Prize.Brain structure & function · 2022Article
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7 authors.
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Abstract
Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering identification of homolog structures. We applied quantitative in vitro receptor autoradiography to characterize the receptor architecture of the primary visual and early extrastriate cortex in macaque and human brains, using previously published cytoarchitectonic criteria as starting point of our analysis. We identified 8 receptor architectonically distinct areas in the macaque brain (mV1d, mV1v, mV2d, mV2v, mV3d, mV3v, mV3A, mV4v), and their respective counterpart areas in the human brain (hV1d, hV1v, hV2d, hV2v, hV3d, hV3v, hV3A, hV4v). Mean densities of 14 neurotransmitter receptors were quantified in each area, and ensuing receptor fingerprints used for multivariate analyses. The 1st principal component segregated macaque and human early visual areas differ. However, the 2nd principal component showed that within each species, area-specific differences in receptor fingerprints were associated with the hierarchical processing level of each area. Subdivisions of V2 and V3 were found to cluster together in both species and were segregated from subdivisions of V1 and from V4v. Thus, comparative studies like this provide valuable architectonic insights into how differences in underlying microstructure impact evolutionary changes in functional processing of the primate brain and, at the same time, provide strong arguments for use of macaque monkey brain as a suitable animal model for translational studies.
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