ArticleNature metabolism2021
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity.
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Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64citing papers in PubMed
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64 citing papers in PubMed, 93 citations in OpenAlex.
- Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese.JCI insight · 2022Trial
- Neuroendocrine regulation of appetite and energy balance in metabolic disorders.IBRO neuroscience reports · 2026Review
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Connexins in metabolic control: linking brain cellular communication to systemic homeostasis.Life medicine · 2026Review
- Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026Review
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- AgRP neuron activity predicts and tracks the glycemic response to oral glucose.Molecular metabolism · 2026Article
- Neurovascular plasticity as a modulator of hypothalamic function.Reviews in endocrine & metabolic disorders · 2026Review
- The role of tanycytes in the regulation of energy balance.Reviews in endocrine & metabolic disorders · 2026Review
- Hypothalamus-liver talks: whispers in the language of metabolism.Reviews in endocrine & metabolic disorders · 2026Review
- Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistance.bioRxiv : the preprint server for biology · 2026Article
- Methodological Challenges for Ablation of BMPR1A in Hypothalamic Tanycytes-A Cautionary Tale.FASEB bioAdvances · 2026Article
- Tanycytic degeneration impairs tau clearance and contributes to Alzheimer's disease pathology.Cell press blue · 2026Article
- AgRP Neuron Activity Predicts and Tracks the Glycemic Response to Oral Glucose.bioRxiv : the preprint server for biology · 2026Article
- Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery.Nature metabolism · 2026Article
- Plasma GLP-1 (Glucagon-like Peptide-1) Depletion Is Correlated with Dysregulation of Adipocytokine in Type 2 Diabetic Patients With or Without Metabolic-Associated Fatty Liver Disease (MAFLD): A Cross-Sectional Study Related to Gender-Sex Disparities.International journal of molecular sciences · 2026Article
- A Novel Cell-Cell Communication Structure: Tanycyte and Cilia Hypothalamic Unifying Glia-cilia Structure (HUGS).microPublication biology · 2026Article
- The Central Role of Lipid Metabolism Disorders in Diabetes Mellitus: Mechanisms, Clinical Manifestations, and Emerging Therapeutic Strategies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Expanding the understanding of insulin resistance in brain and periphery.Trends in endocrinology and metabolism: TEM · 2026Review
- The unanticipated role of the glial-associated glucose-6-phosphatase system in brain homeostasis.iScience · 2025Review
4 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 5 institutions in 3 countries.
Marta Porniece KumarDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0003-2330-5846
Anna Lena CremerDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
Paul KlemmDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0002-5985-1737
Lukas SteuernagelDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0003-0043-1436
Sivaraj SundaramInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Alexander JaisDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0002-9897-4983
A Christine HausenDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0002-5700-7313
Jenkang TaoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Anna SecherGlobal Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.ORCID http://orcid.org/0000-0002-6276-5389
Thomas Åskov PedersenGlobal Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.
Markus SchwaningerInstitute for Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-4510-9718
F Thomas WunderlichDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.ORCID http://orcid.org/0000-0002-9209-3501
Bradford B LowellDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Heiko BackesDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany.
Jens C BrüningDepartment of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany. bruening@sf.mpg.de.ORCID http://orcid.org/0000-0002-6619-0092
Max Planck Institute for Metabolism Research · DEBeth Israel Deaconess Medical Center · USNovo Nordisk (Denmark) · DKUniversity of Lübeck · DEHelmholtz Zentrum München · DE
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MThe routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MNeurocircuitry Underlying Leptin Regulation of Energy BalanceR01DK089044 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2010 to 2023
$6.0MLeveraging the Rich Genetic Diversity of Vagal Motor Neurons to Decode Brain-to-Gut CommunicationR01DK122976 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LIBERLES, STEPHEN DANIEL, LOWELL, BRADFORD B · 2019 to 2023
$3.6MGlutamatergic Neurons in the Arcuate Nucleus (ARC) and Regulation of SatietyR01DK111401 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2016 to 2020
$2.2MTranscriptomic Identification of Vagal Motor Neurons That Differentially Regulate Gastric FunctionF31DK122620 · NIDDK · HARVARD MEDICAL SCHOOL · PI TAO, JENKANG · 2020 to 2021
$66kNIDDK NIH HHS F31 DK122620NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK089044NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK111401NIDDK NIH HHS R01 DK122976
Abstract
Insulin acts on neurons and glial cells to regulate systemic glucose metabolism and feeding. However, the mechanisms of insulin access in discrete brain regions are incompletely defined. Here we show that insulin receptors in tanycytes, but not in brain endothelial cells, are required to regulate insulin access to the hypothalamic arcuate nucleus. Mice lacking insulin receptors in tanycytes (IR
Indexed as
Signal TransductionAgouti-Related ProteinAnimalsBiomarkersBlood-Brain BarrierCalciumEnergy MetabolismEpendymoglial CellsFluorescent Antibody TechniqueGhrelinGlucoseHypothalamusInsulinInsulin ResistanceMiceMice, KnockoutAgouti-Related ProteinBiomarkersCalciumGhrelinGlucoseInsulinPeptide FragmentsReceptor, Insulin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.