Evidence map›Paper›PMID 34930944›Full record

ArticleScientific reports2021

Contributions of Na

Matthew Alsaloum, Julie I R Labau, Shujun Liu, Mark Estacion, Peng Zhao, Fadia Dib-Hajj, Stephen G Waxman

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  3. Sulfolipid-1 fromJournal of neurophysiology · 2026
    Article
  4. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Nav1.8: Intrinsic limits on the functional effect of abrogation in DRG neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Matthew AlsaloumDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9832-0138
Julie I R LabauDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Shujun LiuDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Mark EstacionDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Peng ZhaoDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Fadia Dib-HajjDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Stephen G WaxmanDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA. Stephen.waxman@yale.edu.ORCID 0000-0001-5718-7177
Yale University · USMaastricht University Medical Centre · NL

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
NCATS NIH HHS UL1 TR001863NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

The inhibition of voltage-gated sodium (Na

Indexed as

Action PotentialsAutopsyCell DifferentiationElectrophysiologyHumansImmunohistochemistryInduced Pluripotent Stem CellsMembrane PotentialsMutationNAV1.8 Voltage-Gated Sodium ChannelNAV1.9 Voltage-Gated Sodium ChannelNeuronsNeurosciencesPainPatch-Clamp TechniquesProtein IsoformsNAV1.8 Voltage-Gated Sodium ChannelNAV1.9 Voltage-Gated Sodium ChannelProtein IsoformsSCN10A protein, humanSCN11A protein, human

Identifiers

PMID34930944
PMCPMC8688473
OpenAlexW4200556008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.