ArticleScientific reports2021
Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Thalamo-cortical synchrony shapes seizure expression in human temporal lobe epilepsy.Nature communications · 2026Article
- Circular mixture model-based characterization of time-of-day seizure patterns during presurgical monitoring.Scientific reports · 2026Article
- Article
- Advances in Thalamic Neuromodulation for Epilepsy: From Mechanisms to Clinical Translation.Epilepsy currents · 2026Article
- Thalamic stereoelectroencephalography: safety, accuracy, and thalamocortical connectivity.medRxiv : the preprint server for health sciences · 2025Article
- Distance of bipolar re-referencing imparts nonlinear frequency-specific influences on intracranial recording signal measurements.Journal of neural engineering · 2025Article
- Article
- Rhythms in Longitudinal Thalamic Recordings are Linked to Seizure Risk.medRxiv : the preprint server for health sciences · 2025Article
- Biomarkers for Epilepsy Deep Brain Stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Review
- Refining centromedian nucleus stimulation for generalized epilepsy with targeting and mechanistic insights from intraoperative electrophysiology.Nature communications · 2025Article
- Epileptiform Activity and Seizure Risk Follow Long-Term Non-Linear Attractor Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Acute to long-term characteristics of impedance recordings during neurostimulation in humans.Journal of neural engineering · 2024Article
- Method for cycle detection in sparse, irregularly sampled, long-term neuro-behavioral timeseries: Basis pursuit denoising with polynomial detrending of long-term, inter-ictal epileptiform activity.PLoS computational biology · 2024Article
- Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes.Brain : a journal of neurology · 2024Article
- Acute to long-term characteristics of impedance recordings during neurostimulation in humans.medRxiv : the preprint server for health sciences · 2024Article
- Seizure forecasting: Bifurcations in the long and winding road.Epilepsia · 2023Review
- Interictal epileptiform discharges contribute to word-finding difficulty in epilepsy through multiple cognitive mechanisms.Epilepsia · 2023Article
- Cyclical underreporting of seizures in patient-based seizure documentation.Annals of clinical and translational neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 3 countries.
Funding
Abstract
Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.