ArticleNPJ biofilms and microbiomes2021
Large-scale characterisation of the pregnancy vaginal microbiome and sialidase activity in a low-risk Chinese population.
Article in NPJ biofilms and microbiomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- Association of vaginal microbiome, cytokines, and spontaneous preterm birth among Chinese women: a nested case-control study.Microbiology spectrum · 2026Article
- Integrated metagenomic and metabolomic profiling of spontaneous preterm birth in Chinese women.Frontiers in microbiology · 2026Article
- Advances in biomonitoring technologies for women's health.Nature communications · 2025Review
- Increased vaginalmSystems · 2025Article
- Vaginal Lactobacillus crispatus in early pregnancy associates with favorable gestational outcomes in a Japanese maternal-neonatal microbiome cohort.Nature communications · 2025Article
- Metagenomic analysis reveals the novel role of vaginal Lactobacillus iners in Chinese healthy pregnant women.NPJ biofilms and microbiomes · 2025Article
- Previse preterm birth in early pregnancy through vaginal microbiome signatures using metagenomics and dipstick assays.iScience · 2024Article
- Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy.Scientific reports · 2024Article
- Article
- Vaginal Microbiome and Pregnancy Complications: A Review.Journal of clinical medicine · 2024Review
- Vaginal microbiota are associated with in vitro fertilization during female infertility.iMeta · 2024Article
- Article
- The role of sialidases in the pathogenesis of bacterial vaginosis and their use as a promising pharmacological target in bacterial vaginosis.Frontiers in cellular and infection microbiology · 2024Review
- Compositional Changes in the Vaginal Bacterial Microbiome of Healthy Pregnant Women across the Three Gestational Trimesters in Ismailia, Egypt.Microorganisms · 2023Article
- Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth.Frontiers in immunology · 2023Review
- Interactions between microbiota and cervical epithelial, immune, and mucus barrier.Frontiers in cellular and infection microbiology · 2023Review
- Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health.Microbiology and molecular biology reviews : MMBR · 2022Review
- N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status.Scientific reports · 2022Article
- Relationship Between Vaginal Microbiome and Preterm Birth During Pregnancy: In Different Ethnic Populations.Women's health reports (New Rochelle, N.Y.)Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Vaginal microbiota-host interactions are linked to preterm birth (PTB), which continues to be the primary cause of global childhood mortality. Due to population size, the majority of PTB occurs in Asia, yet there have been few studies of the pregnancy vaginal microbiota in Asian populations. Here, we characterized the vaginal microbiome of 2689 pregnant Chinese women using metataxonomics and in a subset (n = 819), the relationship between vaginal microbiota composition, sialidase activity and leukocyte presence and pregnancy outcomes. Vaginal microbiota were most frequently dominated by Lactobacillus crispatus or L. iners, with the latter associated with vaginal leukocyte presence. Women with high sialidase activity were enriched for bacterial vaginosis-associated genera including Gardnerella, Atopobium and Prevotella. Vaginal microbiota composition, high sialidase activity and/or leukocyte presence was not associated with PTB risk suggesting underlying differences in the vaginal microbiota and/or host immune responses of Chinese women, possibly accounting for low PTB rates in this population.
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