Evidence map›Paper›PMID 34930904›Full record

ArticleTranslational psychiatry2021

Differential brain ADRA2A and ADRA2C gene expression and epigenetic regulation in schizophrenia. Effect of antipsychotic drug treatment.

Iria Brocos-Mosquera, Patricia Miranda-Azpiazu, Carolina Muguruza, Virginia Corzo-Monje, Benito Morentin, J Javier Meana, Luis F Callado, Guadalupe Rivero

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. The pharmacology underlying the unique antipsychotic efficacy of clozapine.Journal of psychopharmacology (Oxford, England) · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Iria Brocos-MosqueraDepartment of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain.
Patricia Miranda-AzpiazuDepartment of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-8620-1772
Carolina MuguruzaDepartment of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-0477-5757
Virginia Corzo-MonjeDepartment of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain.
Benito MorentinSection of Forensic Pathology, Basque Institute of Legal Medicine, Bilbao, Spain.
J Javier MeanaDepartment of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0002-7913-6714
Luis F CalladoDepartment of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain.ORCID http://orcid.org/0000-0001-9941-012X
Guadalupe RiveroDepartment of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain. guadalupe.rivero@ehu.eus.ORCID http://orcid.org/0000-0002-2537-4047
University of the Basque Country · ESBioCruces Health research Institute · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postsynaptic α

Indexed as

Antipsychotic AgentsSchizophreniaAnimalsBrainDorsolateral Prefrontal CortexEpigenesis, GeneticGene ExpressionGene Expression RegulationRatsAntipsychotic Agents

Identifiers

PMID34930904
PMCPMC8688495
OpenAlexW4200241854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.