Evidence map›Paper›PMID 34930893›Full record

Trial reportTranslational psychiatry2021

INTERSTAARS: Attention training for infants with elevated likelihood of developing ADHD: A proof-of-concept randomised controlled trial.

Amy Goodwin, Emily J H Jones, Simona Salomone, Luke Mason, Rebecca Holman, Jannath Begum-Ali, Anna Hunt, Martin Ruddock, George Vamvakas, Emily Robinson and 10 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Amy GoodwinInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. amy.l.goodwin@kcl.ac.uk.ORCID 0000-0003-2585-8452
Emily J H JonesCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK. e.jones@bbk.ac.uk.ORCID 0000-0001-5747-9540
Simona SalomoneCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Luke MasonCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Rebecca HolmanCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Jannath Begum-AliCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Anna HuntDepartment of Psychology, University of Southampton, Southampton, UK.ORCID 0000-0002-0864-4113
Martin RuddockDepartment of Psychology, University of Southampton, Southampton, UK.
George VamvakasInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Emily RobinsonInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Catherine J HoldenCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Chloë TaylorCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Tim J SmithCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK.
Edmund Sonuga-BarkeInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Patrick BoltonInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Tony CharmanInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0003-1993-6549
Andrew PicklesInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Sam WassDepartment of Psychology, University of East London, London, UK.ORCID 0000-0002-7421-3493
Mark H JohnsonCentre for Brain and Cognitive Development, Department of Psychology, Birkbeck College, University of London, London, UK. mark.johnson@bbk.ac.uk.
the INTERSTAARS team
Birkbeck, University of London · GBKing's College London · GBUniversity of Southampton · GBQueen Mary University of London · GBUniversity of Cambridge · GBUniversity of East London · GB

Funding

Medical Research Council MR/T003057/1RCUK | Medical Research Council (MRC) MR/K021389/1
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is first diagnosed during middle childhood, when patterns of difficulty are often established. Pre-emptive approaches that strengthen developing cognitive systems could offer an alternative to post-diagnostic interventions. This proof-of-concept randomised controlled trial (RCT) tested whether computerised gaze-based attention training is feasible and improves attention in infants liable to develop ADHD. Forty-three 9- to 16-month-old infants with a first-degree relative with ADHD were recruited (11/2015-11/2018) at two UK sites and randomised with minimisation by site and sex to receive 9 weekly sessions of either (a) gaze-contingent attention training (intervention; n = 20); or (b) infant-friendly passive viewing of videos (control, n = 23). Sessions were delivered at home with blinded outcome assessments. The primary outcome was a composite of attention measures jointly analysed via a multivariate ANCOVA with a combined effect size (ES) from coefficients at baseline, midpoint and endpoint (Registration: ISRCTN37683928 ). Uptake and compliance was good but intention-to-treat analysis showed no significant differences between 20 intervention and 23 control infants on primary (ES -0.4, 95% CI -0.9 to 0.2; Complier-Average-Causal Effect ES -0.6, 95% CI -1.6 to 0.5) or secondary outcomes (behavioural attention). There were no adverse effects on sleep but a small increase in post-intervention session fussiness. Although feasible, there was no support for short-term effects of gaze-based attention training on attention skills in early ADHD. Longer-term outcomes remain to be assessed. The study highlights challenges and opportunities for pre-emptive intervention approaches to the management of ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityAttentionChildHumansInfantTreatment Outcome

Identifiers

PMID34930893
PMCPMC8688472
OpenAlexW4200338643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.