ArticleProceedings of the National Academy of Sciences of the United States of America2021
The biosynthesis of thymol, carvacrol, and thymohydroquinone in Lamiaceae proceeds via cytochrome P450s and a short-chain dehydrogenase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 140 citations in OpenAlex.
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- Biological Characterization and Essential Oil Profiles of Eastern European Cultivars ofMolecules (Basel, Switzerland) · 2026Article
- Thymol: properties, synthesis, mechanism of action, and applications.Frontiers in nutrition · 2026Review
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- Essential oil composition and biological activities of Coridothymus capitatus collected from two locations in Palestine.PloS one · 2026Article
- Ontogenetic regulation of metabolite dynamics inPeerJ · 2026Article
- Integrative chromosome-level genomics and metabolomics uncover regulatory networks linking monoterpenoid biosynthesis and glandular trichome formation inHorticulture research · 2026Article
- Assessing essential oils from Macaronesia: a study on their efficacy against phytopathogenic and obligate biotrophic fungi.Pest management science · 2026Article
- Sustained Antifungal Protection of Peanuts Using Encapsulated Essential Oils.Molecules (Basel, Switzerland) · 2025Article
- Uncovering the Molecular Response of Oregano (Current issues in molecular biology · 2025Article
- Analysis of Pharmacological Properties ofLife (Basel, Switzerland) · 2025Review
- Carvacrol and Thymol, a Synergistic Antimicrobial Activity Against Bacterial and Candida Species.MicrobiologyOpen · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thymol and carvacrol are phenolic monoterpenes found in thyme, oregano, and several other species of the Lamiaceae. Long valued for their smell and taste, these substances also have antibacterial and anti-spasmolytic properties. They are also suggested to be precursors of thymohydroquinone and thymoquinone, monoterpenes with anti-inflammatory, antioxidant, and antitumor activities. Thymol and carvacrol biosynthesis has been proposed to proceed by the cyclization of geranyl diphosphate to γ-terpinene, followed by a series of oxidations via
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