Evidence map›Paper›PMID 34930830›Full record

ArticleeNeuro

L-Type Calcium Channels Contribute to Ethanol-Induced Aberrant Tangential Migration of Primordial Cortical GABAergic Interneurons in the Embryonic Medial Prefrontal Cortex.

Stephanie M Lee, Pamela W L Yeh, Hermes H Yeh

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Assessment of GABANeuroscience letters · 2026
    Article
  2. Article
  3. GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Stephanie M LeeDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0001-6597-7144
Pamela W L YehDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Hermes H YehDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 Hermes.Hsiao-mei.Yeh@dartmouth.edu.
Dartmouth College · US

Funding

The chloride cotransporter NKCC1 in the embryonic etiology and treatment of FASDR01AA027754 · NIAAA · DARTMOUTH COLLEGE · PI YEH, HERMES H · 2019 to 2023
$2.5M
Ethanol Exposure In Utero and Interneuronopathy in the Medial Prefrontal CortexR01AA023410 · NIAAA · DARTMOUTH COLLEGE · PI YEH, HERMES H · 2014 to 2018
$1.9M
Ethanol, chloride, calcium and growth cone dynamics in embryonic GABAergic interneuronsF31AA027694 · NIAAA · DARTMOUTH COLLEGE · PI LEE, STEPHANIE MINYONG · 2019 to 2020
$91k
NIAAA NIH HHS F31 AA027694NIAAA NIH HHS R01 AA023410NIAAA NIH HHS R01 AA027754
6 · The paper itself

Abstract

Exposure of the fetus to alcohol (ethanol) via maternal consumption during pregnancy can result in fetal alcohol spectrum disorders (FASD), hallmarked by long-term physical, behavioral, and intellectual abnormalities. In our preclinical mouse model of FASD, prenatal ethanol exposure disrupts tangential migration of corticopetal GABAergic interneurons (GINs) in the embryonic medial prefrontal cortex (mPFC). We postulated that ethanol perturbed the normal pattern of tangential migration via enhancing GABA

Indexed as

Calcium Channels, L-TypeEthanolAnimalsCerebral CortexEmbryonic DevelopmentFemaleInterneuronsMicePrefrontal CortexPregnancyCalcium Channels, L-TypeEthanolalcoholcalciumcalcium channelsFASDGABAinterneuron

Identifiers

PMID34930830
PMCPMC8805770
OpenAlexW4200359553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.