Evidence map›Paper›PMID 34930389›Full record

ArticleInternational journal of mental health systems2021

Shifting North American drug markets and challenges for the system of care.

R Michael Krausz, Jean N Westenberg, Nickie Mathew, George Budd, James S H Wong, Vivian W L Tsang, Marc Vogel, Conor King, Vijay Seethapathy, Kerry Jang and 1 more

Abstract read
In one paragraph

Article in International journal of mental health systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Sensitivity to change of generic preference-based instruments (EQ-5D-3L, EQ-5D-5L, and HUI3) in the context of treatment for people with prescription-type opioid use disorder in Canada.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Trial
  3. Self-Injury Mortality: Global Ascertainment and Prevention.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Review
  4. Article
  5. Article
  6. Chronic pain among primary fentanyl users: The concept of self-medication.European journal of pain (London, England) · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. A Call for an Evidence-Based Strategy Against the Overdose Crisis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024
    Article
  11. Article
  12. Shifting drug markets in North America - a global crisis in the making?International journal of mental health systems · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

R Michael KrauszDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Jean N WestenbergDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. jwestenb@student.ubc.ca.ORCID http://orcid.org/0000-0002-4720-8402
Nickie MathewDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
George BuddComplex Pain and Addiction Service, Vancouver General Hospital, Vancouver, BC, Canada.
James S H WongDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Vivian W L TsangDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Marc VogelUniversity of Basel Psychiatric Clinics, Basel, Switzerland.
Conor KingVictoria Police Department, Victoria, BC, Canada.
Vijay SeethapathyDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Kerry JangDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Fiona ChoiDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug markets are dynamic systems which change based on demand, competition, legislation and revenue. Shifts that are not met with immediate and appropriate responses from the healthcare system can lead to public health crises with tragic levels of morbidity and mortality, as experienced Europe in the early 1990s and as is the case in North America currently. The major feature of the current drug market shift in North America is towards highly potent synthetic opioids such as fentanyl and fentanyl analogues. An additional spike in stimulant use further complicates this issue. Without understanding the ever-changing dynamics of drug markets and consequent patterns of drug use, the healthcare system will continue to be ineffective in its response, and morbidity and mortality will continue to increase. Economic perspectives are largely neglected in research and clinical contexts, but better treatment alternatives need to consider the large-scale macroeconomic conditions of drug markets as well as the behavioural economics of individual substance use. It is important for policy makers, health authorities, first responders and medical providers to be aware of the clinical implications of drug market changes in order to best serve people who use drugs. Only with significant clinical research, a comprehensive reorganization of the system of care across all sectors, and an evidence-driven governance, will we be successful in addressing the challenges brought on by the recent shifts in drug markets.

Indexed as

Drug marketsDrug policyFentanylOverdosePublic health crisis

Identifiers

PMID34930389
PMCPMC8685808

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.