Evidence map›Paper›PMID 34930356›Full record

ArticleNutrition & metabolism2021

Association of serum choline levels and all-cause mortality risk in adults with hypertension: a nested case-control study.

Mengmeng Song, Benjamin P Xu, Qiongyue Liang, Yaping Wei, Yun Song, Ping Chen, Ziyi Zhou, Nan Zhang, Qiangqiang He, Lishun Liu and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00794885 (Enalapril Maleate and Folic Acid Tablets for Primary Prevention of Stroke in Patients With Hypertension), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00794885 phase4completednot on this map

Enalapril Maleate and Folic Acid Tablets for Primary Prevention of Stroke in Patients With Hypertension: a Post-marketing, Double-blind, Randomized Controlled Trial.

TypeinterventionalSponsorShenzhen Ausa Pharmed Co.,LtdRan2008 to 2014Enrolled20,702ConditionsPrimary HypertensionArmsEnalapril/folic acid, Enalapril maleate
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Cholinergic Polarization of Human Macrophages.International journal of molecular sciences · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Mengmeng SongDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, China.
Benjamin P XuDepartment of Epidemiology and Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, 02115, USA.
Qiongyue LiangState Key Laboratory of Natural Medicines, Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Yaping WeiKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yun SongInstitute for Biomedicine, Anhui Medical University, Hefei, China.
Ping ChenCollege of Pharmacy, Jinan University, Guangzhou, China.
Ziyi ZhouShenzhen Evergreen Medical Institute, Shenzhen, China.
Nan ZhangDepartment of Epidemiology and Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, 02115, USA.
Qiangqiang HeShenzhen Evergreen Medical Institute, Shenzhen, China.
Lishun LiuShenzhen Evergreen Medical Institute, Shenzhen, China.
Tong LiuDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, China.
Kangping ZhangDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, China.
Chunlei HuDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, China.
Binyan WangInstitute for Biomedicine, Anhui Medical University, Hefei, China.
Xiping XuKey Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. xipingxu126@126.com.
Hanping ShiDepartment of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, China. shihp@ccmu.edu.cn.ORCID http://orcid.org/0000-0003-4514-8693
Capital Medical University · CNUniversity Town of Shenzhen · CNAnhui Medical University · CNHarvard University · USChina Agricultural University · CNChina International Science and Technology Cooperation · CNChina Pharmaceutical University · CNJinan University · CNMinistry of Education · SA

Funding

Department of Science and Technology of Guangdong Province 2020B121202010Economic, Trade and Information Commission of Shenzhen Municipality 20170505160926390Economic, Trade and Information Commission of Shenzhen Municipality 20170505161556110Economic, Trade and Information Commission of Shenzhen Municipality 201705051617070National Key Research and Development Program 2016YFE0205400National Key Research and Development Program 2018ZX09301034003National Key Research and Development Program 2018ZX09739010Science and Technology Planning Project of Guangzhou 201707020010Science, Technology and Innovation Committee of Shenzhen GJHS20170314114526143Science, Technology and Innovation Committee of Shenzhen JSGG20180703155802047
6 · The paper itself

Abstract

backgroundSerum choline levels were associated with multiple chronic diseases. However, the association between serum choline and all-cause mortality in Chinese adults with hypertension remains unclear. The purpose of this study is to explore the association between serum choline concentrations and all-cause mortality risk in Chinese adults with hypertension, a high-risk population.

methodsA nested, case-control study was conducted that included 279 patients with all-cause death, and 279 matched, living controls, derived from the China Stroke Primary Prevention Trial (CSPPT). Baseline serum choline concentrations were measured by liquid chromatography with tandem quadrupole mass spectrometry (LC-MS/MS). Multivariate logistic regression analysis was used to assess the association of serum choline levels and all-cause mortality risk, with adjustment of pertinent covariables, including folic acid and homocysteine.

resultsThe median age of all participants was 64.13 years [interquartile range (IQR), 57.33-70.59 years]. The median serum choline concentration for cases (9.51 μg/mL) was higher than that in controls (7.80 μg/mL) (P = 0.009). When serum choline concentration was assessed as a continuous variable (per SD increased), there was a positive relation between serum choline levels and all-cause mortality risk [odds ratios (OR), 1.29; 95% confidence intervals (95%CI), 1.06-1.57; P = 0.010]. There was an increased all-cause mortality risk for participants in quartiles 2-4 (≥ 4.00 μg/mL; OR, 1.79; 95%CI, 1.15-2.78 compared with quartile 1 (< 4.00 μg/mL). In addition, non-drinking was found to promote the incidence of all-cause mortality for those with high choline concentrations.

conclusionsHigh serum choline concentrations were associated with increased all-cause mortality risk among Chinese adults with hypertension, compared to lower choline concentrations. Trial registration clinicaltrials.gov Identifier: NCT007948885; UTL: https://clinicaltrials.gov/ct2/show/NCT00794885?term=NCT00794885&draw=2&rank=1.

Indexed as

All-cause mortalityHypertensionNested case–controlSerum choline

Identifiers

PMID34930356
PMCPMC8686288
OpenAlexW4200186712

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.