ArticleLipids in health and disease2021
Higher fasting triglyceride predicts higher risks of diabetes mortality in US adults.
Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Integrated Analysis of Rat Pulmonary Hypertension Datasets Identifies Candidate circRNA Networks in Hypoxia-Exposed Pulmonary Artery Tissue.International journal of molecular sciences · 2026Article
- Special Issue "The Role of Lipids in Health and Diseases".International journal of molecular sciences · 2026Article
- Non-Fasting Glucose Measures and Their Clinical Significance in Diabetes Diagnosis and Cardiovascular and Cancer Risk Prediction: A Narrative Review.International journal of molecular sciences · 2026Review
- A correlation analysis between TyG-derived indices and diabetes mellitus: based on the NHANES database.Endocrine journal · 2026Article
- Role of Circulating Lipids in Mediating the Diabetogenic Effect of Obesity.Biomedicines · 2025Article
- Special Issue "New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 3rd Edition".International journal of molecular sciences · 2025Article
- Triglycerides, Glucose Metabolism, and Type 2 Diabetes.International journal of molecular sciences · 2025Review
- The association between plasma lipidome and diabetic microangiopathy: a mendelian randomization study.Acta diabetologica · 2025Article
- Neuroimmune Interactions and Their Role in Immune Cell Trafficking in Cardiovascular Diseases and Cancer.International journal of molecular sciences · 2025Review
- Special Issue: "New Trends in Diabetes, Hypertension, and Cardiovascular Diseases-2nd Edition".International journal of molecular sciences · 2025Article
- Association Between Triglyceride and Incident Diabetes Mellitus: A Secondary Retrospective Analysis Based on a Chinese Cohort Study.Journal of multidisciplinary healthcare · 2025Article
- Untargeted and Targeted Lipidomics Unveil Dynamic Lipid Metabolism Alterations in Type 2 Diabetes.Metabolites · 2024Article
- Investigation of the risk factors associated with prediabetes in normal-weight Qatari adults: a cross-sectional study.Scientific reports · 2024Article
- Postprandial Plasma Glucose between 4 and 7.9 h May Be a Potential Diagnostic Marker for Diabetes.Biomedicines · 2024Article
- LINC317.5 as a novel biomarker for hypertriglyceridemia in normal glucose metabolism.Cell death discovery · 2024Article
- Fasting Triglycerides in the Upper Normal Range Are Independently Associated with an Increased Risk of Diabetes Mortality in a Large Representative US Population.Journal of cardiovascular development and disease · 2024Article
- Homeostasis Model Assessment for Insulin Resistance Mediates the Positive Association of Triglycerides with Diabetes.Diagnostics (Basel, Switzerland) · 2024Article
- Postprandial Plasma Glucose Measured from Blood Taken between 4 and 7.9 h Is Positively Associated with Mortality from Hypertension and Cardiovascular Disease.Journal of cardiovascular development and disease · 2024Article
- Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes.Cardiovascular research · 2023Article
- Dietary fatty acids and mortality risk from heart disease in US adults: an analysis based on NHANES.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unknown whether higher triglyceride results in higher mortality from diabetes, i.e., diabetes mortality. This study aimed to investigate the association of fasting triglyceride with diabetes mortality.
methodsThis study included 26,582 US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. Diabetes mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglyceride for diabetes mortality.
resultsHigher levels of fasting triglyceride were associated with higher levels of glucose, glycated hemoglobin, insulin, and homeostatic model assessment for insulin resistance at baseline. A 1-natural-log-unit increase in triglyceride (e.g., from 70 to 190 mg/dL) was associated with a 115% higher multivariate-adjusted risk of diabetes diagnosis (odds ratio, 2.15; 95% CI, 2.00-2.33). During 319,758 person-years of follow-up with a mean follow-up of 12.0 years, 582 diabetes deaths were documented. Compared with people with triglyceride in the lowest quintile, people with triglyceride in the highest quintile had an 85% higher risk of diabetes mortality (HR, 1.85; 95% CI, 1.25-2.73). A 1-natural-log-unit increase in triglyceride was associated with a 40% higher multivariate-adjusted risk of diabetes mortality. The positive association between triglyceride and diabetes mortality was also presented in sub-cohorts of participants with or without diabetes.
conclusionsThis study demonstrated that higher fasting triglyceride was associated with a higher diabetes mortality risk.
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