Evidence map›Paper›PMID 34930279›Full record

ArticleJournal of nanobiotechnology2021

A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy.

Yue Hua, Yuan Wang, Xue Kang, Fan Xu, Zhen Han, Chong Zhang, Zhao-Yang Wang, Jun-Qi Liu, Xueli Zhao, Xiaoyuan Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Golden era of radiosensitizers.Frontiers in veterinary science · 2024
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Assembling AuJournal of nanobiotechnology · 2024
    Article
  9. Review
  10. Ultrasmall PtAuTheranostics · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue HuaHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Yuan WangHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Xue KangHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Fan XuHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Zhen HanHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Chong ZhangHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Zhao-Yang WangHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China.
Jun-Qi LiuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Xueli ZhaoHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. xuelizhao@zzu.edu.cn.
Xiaoyuan ChenDepartments of Diagnostic Radiology, Chemical and Biomolecular Engineering, and Biomedical Engineering, National University of Singapore, Singapore, 117545, Singapore. chen.shawn@nus.edu.sg.
Shuang-Quan ZangHenan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. zangsqzg@zzu.edu.cn.

Funding

China National Funds for Distinguished Young Scientists 21825106Key Programme 92061201NUS School of Medicine Nanomedicine Translational Research Programme NUHSRO/2021/034/TRP/09/NanomedicinePostdoctoral Research Foundation of China 2019M652562the National University of Singapore Start-up Grant NUHSRO/2020/133/Startup/08the Program for Science & Technology Innovation Talents in Universities of Henan Province 164100510005Young Scientists Fund 22001235
6 · The paper itself

Abstract

backgroundAs cancer is one of the main leading causes of mortality, a series of monotherapies such as chemotherapy, gene therapy and radiotherapy have been developed to overcome this thorny problem. However, a single treatment approach could not achieve satisfactory effect in many experimental explorations.

resultsIn this study, we report the fabrication of cyclic RGD peptide (cRGD) modified Au

conclusionsThe successful dual-modal imaging and combined tumor therapy demonstrated AIE as a promising strategy for constructing multifunctional cancer theranostic platform.

Indexed as

AnimalsCell Line, TumorCell SurvivalFemaleFerric CompoundsGoldHumansHydrogen PeroxideIronMagnetic Resonance ImagingMiceMice, Inbred BALB CNanoparticlesNeoplasmsOligopeptidesPhotochemotherapyarginyl-glycyl-aspartic acidFenton's reagentFerric Compoundsferric oxideGoldHydrogen PeroxideIronOligopeptidesRadiation-Sensitizing AgentsAggregation-induced emission (AIE)AssembliesFenton reactionRadiosensitizerTherapy

Identifiers

PMID34930279
PMCPMC8686291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.