Evidence map›Paper›PMID 34930033›Full record

ArticleAntimicrobial agents and chemotherapy2022

High Prevalence of OXA-23 Carbapenemase-Producing

Amélie Lombes, Rémy A Bonnin, Frédéric Laurent, Hélène Guet-Revillet, Emmanuelle Bille, Vincent Cattoir, Marie-Sarah Fangous, Cécile Le Brun, Vincent Fihman, Frédéric Janvier and 7 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Detection of blaEmerging infectious diseases · 2026
    Article
  2. Review
  3. Detection of OXA-23 and OXA-58 inMicrobiology spectrum · 2026
    Article
  4. Tackling Drug Resistance and Virulence inThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 1 country.

Amélie LombesCHU de Bicêtre, Laboratoire de Bactériologie-Hygiène, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France.
Rémy A BonninINSERM UMR 1184, Team RESIST, Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Frédéric LaurentHospices Civils de Lyon, Department de Bactériologie, Institut des Agents infectieux, Lyon, France.
Hélène Guet-RevilletHôpital Purpan, Laboratoire de Bactériologie-Hygiène, Toulouse, France.
Emmanuelle BilleCHU Necker-Enfants Malades, Laboratoire de Microbiologie, Assistance Publique des Hôpitaux de Paris, Paris, France.
Vincent CattoirCHU de Rennes, Service de Bactériologie-Hygiène Hospitalière, Rennes, France.ORCID 0000-0003-4026-9912
Marie-Sarah FangousCentre Hospitalier de Cornouaille, Laboratoire de biologie médicale, Quimper, France.ORCID 0000-0002-0064-9438
Cécile Le BrunCHRU de Tours, Hôpital Bretonneau, Service de Bactériologie-Virologie-Hygiène, Tours, France.ORCID 0000-0002-9846-0210
Vincent FihmanCHU Henri Mondor, Service de Bactériologie-Virologie-Hygiène, Créteil, France.
Frédéric JanvierHôpital d'Instruction des Armées Sainte-Anne, Service de Microbiologie et Hygiène Hospitalière, Toulon, France.
Marie-Pierre OttoHôpital d'Instruction des Armées Sainte-Anne, Service de Microbiologie et Hygiène Hospitalière, Toulon, France.
Anais PotronCentre National de Référence de la Résistance aux Antibiotiques, Laboratoire de Bactériologie, CHU de Besançon, Besançon, France.ORCID 0000-0002-2966-7947
Stéphane CorvecCHU de Nantes, Service de Bactériologie et des Contrôles Microbiologiques, Nantes, France.ORCID 0000-0003-3176-8111
Louise Ruffier d'EpenouxCHU de Nantes, Service de Bactériologie et des Contrôles Microbiologiques, Nantes, France.
Assaf MizrahiService de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
Laurent DortetCHU de Bicêtre, Laboratoire de Bactériologie-Hygiène, Assistance Publique des Hôpitaux de Paris, Le Kremlin-Bicêtre, France.ORCID 0000-0001-6596-7384
GMC Study Group
Inserm · FRCentre Hospitalier Universitaire de Nantes · FRHôpital d'Instruction des Armées Sainte-Anne · FRAgroParisTech · FRCentre Hospitalier de Cornouaille · FRCentre Hospitalier Universitaire de Rennes · FRCentre Hospitalier Universitaire de Tours · FRCentre Hospitalier Universitaire Henri-Mondor · FRCNR de la Résistance aux Antibiotiques · FRHôpital Necker-Enfants Malades · FRHôpital Purpan · FRHospices Civils de Lyon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin-clavulanate-resistant Proteus mirabilis isolates produced the OXA-23 carbapenemase. We found that an inhibition zone diameter of <11 mm around the amoxicillin-clavulanate disc was an accurate screening cutoff to detect these OXA-23 producers. We confirmed by whole-genome sequencing that these OXA-23-producers all belonged to the same lineage that has been demonstrated to disseminate OXA-23 or OXA-58 in P. mirabilis.

Indexed as

beta-LactamasesProteus mirabilisAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial AgentsBacterial ProteinsMicrobial Sensitivity TestsPrevalenceAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseAcinetobactercarbapenemaseepidemiologyinfectious clonesOXA-23Proteae

Identifiers

PMID34930033
PMCPMC8846483
OpenAlexW4200319081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.