ArticleNature2022
Structural architecture of the human NALCN channelosome.
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In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the PreBötzinger Complex of the Ventrolateral Medulla.Molecular neurobiology · 2026Article
- Novel circUnc79 regulates morphine-induced reward memoryActa pharmaceutica Sinica. B · 2026Article
- The NALCN channel complex is necessary for stabilizing sleep in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2026Article
- Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the preBötzinger Complex of the Ventrolateral Medulla.Research square · 2026Article
- SMCHD1 loss re-wires MYOD1 enhancer nexuses and chromatin accessibility landscapes in muscle cells.bioRxiv : the preprint server for biology · 2026Article
- NALCN/Cch1 channelosome subunits originated in early eukaryotes.The Journal of general physiology · 2025Article
- Article
- Genome-Wide Association Studies in Japanese Quails of the FInternational journal of molecular sciences · 2025Article
- SMCHD1 maintains heterochromatin, genome compartments and epigenome landscape in human myoblasts.Nature communications · 2025Article
- Article
- Defining molecular signatures of the solid/pseudopapillary and pseudoglandular patterns in so-called "solid-tubulocystic intrahepatic cholangiocarcinoma vs. NIPBL::NACC1 fusion hepatic carcinoma".Pathology, research and practice · 2025Article
- The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins.Science advances · 2025Article
- Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Two rare autosomal recessive neurological disorders identified by combined genetic approaches in a single consanguineous family with multiple offspring.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- 1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit.International journal of molecular sciences · 2024Article
- Widening the infantile hypotonia with psychomotor retardation and characteristic Facies-1 Syndrome's clinical and molecular spectrum through NALCNFrontiers in genetics · 2024Article
- A governance of ion selectivity based on the occupancy of the "beacon" in one- and four-domain calcium and sodium channels.Channels (Austin, Tex.) · 2023Article
- Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Role of sodium leak channel (NALCN) in sensation and pain: an overview.Frontiers in pharmacology · 2023Review
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 4 countries.
Marc KschonsakDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, USA.
Han Chow ChuaDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4477-174X
Claudia Weidling *Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Nourdine Chakouri *Department Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-8809-8684
Cameron L Noland *Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6364-3167
Katharina SchottDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Timothy ChangDepartment of BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA.
Christine TamDepartment of BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA.
Nidhi PatelDepartment of BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA.
Christopher P ArthurDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, USA.
Alexander LeitnerDepartment of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zurich, Switzerland. leitner@imsb.biol.ethz.ch.ORCID http://orcid.org/0000-0003-4126-0725
Manu Ben-JohnyDepartment Physiology and Cellular Biophysics, Columbia University, New York, NY, USA. mbj2124@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-5645-0815
Claudio CiferriDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, USA. ciferri.claudio@gene.com.ORCID http://orcid.org/0000-0002-0804-2411
Stephan Alexander PlessDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. stephan.pless@sund.ku.dk.ORCID http://orcid.org/0000-0001-6654-114X
Jian PayandehDepartment of Structural Biology, Genentech Inc., South San Francisco, CA, USA. jpayandeh@interlinetx.com.ORCID http://orcid.org/0000-0002-4015-9716
University of Copenhagen · DKColumbia University · USColumbia University Irving Medical Center · USETH Zurich · CHGene Therapy Laboratory · FRGlaxoSmithKline (United States) · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US
Funding
Tuning of CaV channel dynamics by stac proteinsR01NS110672 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHNY, MANU BEN · 2019 to 2023
$1.7MNINDS NIH HHS R01 NS110672
Abstract
Depolarizing sodium (Na
Indexed as
Ion ChannelsMembrane ProteinsAmino Acid MotifsCalmodulinCarrier ProteinsHumansIon Channel GatingMembrane PotentialsNeuronsSodiumCalmodulinCarrier ProteinsIon ChannelsMembrane ProteinsNALCN protein, humanNALF1 protein, humanSodiumUnc80 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.