ArticleNeuroImage. Clinical2022
Alterations of dynamic redundancy of functional brain subnetworks in Alzheimer's disease and major depression disorders.
Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 15 citations in OpenAlex.
- Functional redundancy of the posterior hippocampi is selectively disrupted in non-demented older adults withNeuroimage. Reports · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- A bibliometric analysis of research on dementia comorbid with depression from 2005 to 2024.Frontiers in neuroscience · 2025Article
- Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve.Frontiers in aging neuroscience · 2025Article
- Jointly constrained group sparse connectivity representation improves early diagnosis of Alzheimer's disease on routinely acquired T1-weighted imaging-based brain network.Health information science and systems · 2024Article
- Transcutaneous Auricular Vagus Nerve Stimulation Modulating the Brain Topological Architecture of Functional Network in Major Depressive Disorder: An fMRI Study.Brain sciences · 2024Article
- Small vessel disease and cognitive reserve oppositely modulate global network redundancy and cognitive function: A study in middle-to-old aged community participants.Human brain mapping · 2024Article
- Atypical Functional Network Properties and Associated Dimensions of Child Psychopathology During Rest and Task Performance.Biological psychiatry global open science · 2023Article
- Accumulation of network redundancy marks the early stage of Alzheimer's disease.Human brain mapping · 2023Article
- Investigating the predictive models of efficacy of accelerated neuronavigation-guided rTMS for suicidal depression based on multimodal large-scale brain networks.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human brain is not only efficiently but also "redundantly" connected. The redundancy design could help the brain maintain resilience to disease attacks. This paper explores subnetwork-level redundancy dynamics and the potential of such metrics in disease studies. As such, we looked into specific functional subnetworks, including those associated with high-level functions. We investigated how the subnetwork redundancy dynamics change along with Alzheimer's disease (AD) progression and with major depressive disorder (MDD), two major disorders that could share similar subnetwork alterations. We found an increased dynamic redundancy of the subcortical-cerebellum subnetwork and its connections to other high-order subnetworks in the mild cognitive impairment (MCI) and AD compared to the normal control (NC). With gained spatial specificity, we found such a redundancy index was sensitive to disease symptoms and could act as a protective mechanism to prevent the collapse of the brain network and functions. The dynamic redundancy of the medial frontal subnetwork and its connections to the frontoparietal subnetwork was also found decreased in MDD compared to NC. The spatial specificity of the redundancy dynamics changes may provide essential knowledge for a better understanding of shared neural substrates in AD and MDD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.