Evidence map›Paper›PMID 34929486›Full record

ArticleAddictive behaviors2022

Maternal trajectories of cannabis use and young adult cannabis and nicotine dependence.

Natacha M De Genna, Lidush Goldschmidt, Gale A Richardson, Nancy L Day

Open access · greenAbstract read
In one paragraph

Article in Addictive behaviors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Natacha M De GennaDepartment of Psychiatry, University of Pittsburgh School of Medicine and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA. 3811 O'Hara St, Pittsburgh, PA 15213, United States. Electronic address: degennanm@upmc.edu.
Lidush GoldschmidtUniversity of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.
Gale A RichardsonDepartment of Psychiatry, University of Pittsburgh School of Medicine and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA, United States.
Nancy L DayDepartment of Psychiatry, University of Pittsburgh School of Medicine and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA, United States.
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

PRENATAL MARIJUANA EXPOSURE: LONG-TERM OUTCOMESR01DA017786 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAY, NANCY LEE · 2005 to 2009
$2.4M
Maternal Age, Trajectories of Substance Use, and Health DisparitiesR01DA037209 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DE GENNA, NATACHA · 2014 to 2016
$864k
ALCOHOL USE DURING PREGNANCY: A LONGITUDINAL STUDYR01AA006666 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAY, NANCY L · 1985 to 2002
$544k
Effects of Prenatal Alcohol Exposure at 22 YearsR01AA018116 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAY, NANCY LEE · 2009 to 2010
$358k
NIAAA NIH HHS R01 AA006666NIAAA NIH HHS R01 AA018116NIDA NIH HHS R01 DA017786NIDA NIH HHS R01 DA037209
6 · The paper itself

Abstract

introductionThe goals of this study were to model maternal patterns of cannabis use from one year pre-pregnancy to 16 years postpartum and to determine if different patterns of maternal cannabis use predicted offspring substance use at age 22.

methodsWomen were recruited from a prenatal clinic between 1982 and 1984. Maternal cannabis use was assessed by trained interviewers twice during pregnancy, at delivery, 8 and 18 months, 3, 6, 10, 14, and 16 years postpartum. At age 22, substance use and dependence were measured in offspring. Growth mixture models of maternal cannabis use were calculated and adult offspring substance use outcomes were regressed onto maternal cannabis trajectory classes (n = 551).

resultsThere were five distinct patterns of maternal cannabis use. Offspring of mothers who were chronic cannabis users were more likely to use cannabis (p < 0.001) and develop CUD (p < 0.05) than offspring whose mothers did not use cannabis. Offspring of chronic cannabis users were also more likely to be nicotine dependent by age 22 than offspring whose mothers did not use cannabis (p < 0.01) and than offspring whose mothers were decreasingly likely to use over time (p < 0.01).

conclusionsIntegrated variable- and person-centered analyses revealed long-term and meaningful patterns of cannabis use and desistance. Chronic maternal cannabis use is a risk factor for regular and dependent cannabis use and for dependent tobacco use among young adult offspring. These findings have implications for maternal-child health given the increasing prevalence of cannabis use among women.

Indexed as

CannabisHallucinogensTobacco Use DisorderAdultFemaleHumansMothersPregnancyTobacco UseYoung AdultHallucinogensCannabisDependenceInter-generationalMaternalTobaccoTrajectories

Identifiers

PMID34929486
PMCPMC8802558
OpenAlexW4200569287

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.