Evidence map›Paper›PMID 34929105›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Distinct features of brain perivascular fibroblasts and mural cells revealed by

Stephanie K Bonney, Liam T Sullivan, Timothy J Cherry, Richard Daneman, Andy Y Shih

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 59 citations in OpenAlex.

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  16. Imatinib on target in stroke recovery.The Journal of clinical investigation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Stephanie K BonneyCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.
Liam T SullivanCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.
Timothy J CherryCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.
Richard DanemanDepartments of Neurosciences and Pharmacology, University of California San Diego, La Jolla, CA, USA.
Andy Y ShihCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.
Seattle Children's Hospital · USUniversity of California, San Diego · USUniversity of Washington · US

Funding

Non-Coding Genetic Vulnerabilities in Human Photoreceptor Function and DiseaseR01EY028584 · NEI · SEATTLE CHILDREN'S HOSPITAL · PI CHERRY, TIMOTHY JOEL · 2019 to 2025
$4.2M
Deciphering the Cerebral Microinfarct and its Role in Vascular Cognitive ImpairmentR01NS097775 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI SHIH, ANDY Y · 2017 to 2021
$3.2M
Pericyte structural plasticity and cerebrovascular healthR01AG062738 · NIA · SEATTLE CHILDREN'S HOSPITAL · PI SHIH, ANDY Y · 2020 to 2024
$3.0M
Optimizing Models of Non-Coding Genetic Risk in Age-Related Macular DegenerationR01EY033364 · NEI · SEATTLE CHILDREN'S HOSPITAL · PI TIMOTHY JOEL CHERRY · 2022 to 2026
$2.5M
How do CNS fibroblasts regulate the response to neuroinflammation?R01NS119615 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DANEMAN, RICHARD · 2021 to 2025
$2.4M
Optical Interrogation of Venular Function in Cerebral Gray and White MatterR21AG069375 · NIA · SEATTLE CHILDREN'S HOSPITAL · PI SHIH, ANDY Y, WATERS, JACK · 2020 to 2021
$525k
Cytoskeletal Dynamics of Brain Pericytes and Impact on Capillary FlowR21NS106138 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI SHIH, ANDY Y · 2018 to 2019
$518k
The effects of amyloid beta on pericyte remodeling and brain capillary function in vivoR21AG063031 · NIA · SEATTLE CHILDREN'S HOSPITAL · PI SHIH, ANDY Y · 2019 to 2020
$512k
Cellular Behaviors of Perivascular Fibroblasts in Cerebral IschemiaF32NS117649 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI BONNEY, STEPHANIE · 2020 to 2021
$131k
NEI NIH HHS R01 EY028584NEI NIH HHS R01 EY033364NIA NIH HHS R01 AG062738NIA NIH HHS R21 AG063031NIA NIH HHS R21 AG069375NINDS NIH HHS F32 NS117649NINDS NIH HHS R01 NS097775NINDS NIH HHS R01 NS119615NINDS NIH HHS R21 NS106138
6 · The paper itself

Abstract

Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central nervous system disorders. Like mural cells, PVFs surround blood vessels and express Pdgfrβ. However, these shared attributes hinder the ability to distinguish PVFs from mural cells. We used

Indexed as

CapillariesPericytesAnimalsBrainFibroblastsMiceMice, Transgenicbrain vasculaturecollagen-1pericytesPerivascular fibroblastssmooth muscle cells

Identifiers

PMID34929105
PMCPMC9125487
OpenAlexW4226267268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.