Evidence map›Paper›PMID 34929081›Full record

ArticleJournal of medicinal chemistry2022

Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior.

Thuy Nguyen, Thomas F Gamage, David B Finlay, Ann M Decker, Tiffany L Langston, Daniel Barrus, Michelle Glass, Jun-Xu Li, Terry P Kenakin, Yanan Zhang

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Mechanism of action and treatment of type I interferon in hepatocellular carcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  4. Role of mesolimbic cannabinoid receptor 1 in stress-driven increases in cocaine self-administration in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Thuy NguyenResearch Triangle Institute, Research Triangle Park, Research Triangle Park, North Carolina 27709, United States.ORCID 0000-0002-3961-0901
Thomas F GamageResearch Triangle Institute, Research Triangle Park, Research Triangle Park, North Carolina 27709, United States.
David B FinlayDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.ORCID 0000-0002-3160-2931
Ann M DeckerResearch Triangle Institute, Research Triangle Park, Research Triangle Park, North Carolina 27709, United States.ORCID 0000-0003-1899-6558
Tiffany L LangstonResearch Triangle Institute, Research Triangle Park, Research Triangle Park, North Carolina 27709, United States.
Daniel BarrusResearch Triangle Institute, Research Triangle Park, Research Triangle Park, North Carolina 27709, United States.
Michelle GlassDepartment of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.ORCID 0000-0002-5997-6898
Jun-Xu LiDepartment of Pharmacology and Toxicology, University at Buffalo, the State University of New York, Buffalo, New York 14214, United States.ORCID 0000-0001-8103-7013
Terry P KenakinDepartment of Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Yanan ZhangResearch Triangle Institute, Research Triangle Park, Research Triangle Park, North Carolina 27709, United States.ORCID 0000-0001-7153-4358
RTI International · USUniversity of Otago · NZUniversity at Buffalo, State University of New York · USUniversity of North Carolina at Chapel Hill · US

Funding

Allosteric Modulation of the CB1 ReceptorR01DA040693 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI ZHANG, YANAN · 2016 to 2020
$2.4M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
NIDA NIH HHS K01 DA045752NIDA NIH HHS R01 DA040693
6 · The paper itself

Abstract

We have shown that CB

Indexed as

Allosteric RegulationAnimalsBehavior, AnimalBrainCocaineCocaine-Related DisordersDrug-Seeking BehaviorMaleMicePhenylurea CompoundsRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Vasoconstrictor AgentsCocainePhenylurea CompoundsReceptor, Cannabinoid, CB1Vasoconstrictor Agents

Identifiers

PMID34929081
PMCPMC8969894
OpenAlexW4200272797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.