Evidence map›Paper›PMID 34929080›Full record

ArticleNano letters2022

Quantum Sensing of Free Radicals in Primary Human Dendritic Cells.

Linyan Nie, Anggrek C Nusantara, Viraj G Damle, Maxim V Baranov, Mayeul Chipaux, Claudia Reyes-San-Martin, Thamir Hamoh, Chandra Prakash Epperla, Miroslava Guricova, Petr Cigler and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nano letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Millikelvin Intracellular Nanothermometry with Nanodiamonds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Free radical detection in precision-cut mouse liver slices with diamond-based quantum sensing.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Timing and Mechanisms of Nanodiamond Uptake in Colon Cancer Cells.Nanotechnology, science and applications · 2024
    Article
  19. Robotic Vectorial Field Alignment for Spin-Based Quantum Sensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  20. Metabolically regulated spiking could serve neuronal energy homeostasis and protect from reactive oxygen species.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Linyan NieUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Anggrek C NusantaraUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Viraj G DamleUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Maxim V BaranovUniversity of Groningen, Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Mayeul ChipauxInstitute of Physics, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Claudia Reyes-San-MartinUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.ORCID 0000-0001-7164-1620
Thamir HamohUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Chandra Prakash EpperlaInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague, Czech Republic.
Miroslava GuricovaInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague, Czech Republic.
Petr CiglerInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nam. 2, 166 10 Prague, Czech Republic.
Geert van den BogaartUniversity of Groningen, Department of Molecular Immunology, Groningen Biomolecular Sciences and Biotechnology Institute, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Romana SchirhaglUniversity of Groningen, University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.ORCID 0000-0002-8749-1054
University Medical Center Groningen · NLCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZUniversity of Groningen · NLÉcole Polytechnique Fédérale de Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Free radicals are crucial indicators for stress and appear in all kinds of pathogenic conditions, including cancer, cardiovascular diseases, and infection. However, they are difficult to detect due to their reactivity and low abundance. We use relaxometry for the detection of radicals with subcellular resolution. This method is based on a fluorescent defect in a diamond, which changes its optical properties on the basis of the magnetic surroundings. This technique allows nanoscale MRI with unprecedented sensitivity and spatial resolution. Recently, this technique was used inside living cells from a cell line. Cell lines differ in terms of endocytic capability and radical production from primary cells derived from patients. Here we provide the first measurements of phagocytic radical production by the NADPH oxidase (NOX2) in primary dendritic cells from healthy donors. The radical production of these cells differs greatly between donors. We investigated the cell response to stimulation or inhibition.

Indexed as

NanodiamondsDendritic CellsDiamondFree RadicalsHumansMagneticsDiamondFree RadicalsNanodiamondsmagnetometrynanodiamondsNV centersrelaxometry measurements (T1)

Identifiers

PMID34929080
PMCPMC8880378
OpenAlexW4200385874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.