ArticlePloS one2021
Course of lactate, pH and base excess for prediction of mortality in medical intensive care patients.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Combined metabolic risk and admission lactate-to-bicarbonate ratio in critically ill children: a retrospective pediatric ıntensive care cohort study.European journal of pediatrics · 2026Article
- Heart Rate Variability Integrated into a Longitudinal Multimodal Model to Predict Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.Bioengineering (Basel, Switzerland) · 2026Article
- Baseline Predictors of Adverse Outcome and Survival in Adults Hospitalized with Invasive Pneumococcal Disease.Healthcare (Basel, Switzerland) · 2026Article
- Association between early arterial pH, base excess and lactate and 24-h mortality and neurological outcomes after cardiac arrest and cardiopulmonary resuscitation: a translational study.Resuscitation plus · 2026Article
- Dynamic prognostic prediction in sepsis using longitudinal blood gas trajectories: development and external validation.Frontiers in medicine · 2026Article
- Prognostic Value of Standard Base Excess in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study.International journal of nephrology · 2026Article
- Prognostic value of serial alactic base excess measurements in patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2026Article
- Development and evaluation of a machine learning prediction model for short-term mortality in patients with diabetes or hyperglycemia at emergency department admission.Cardiovascular diabetology · 2025Article
- Association between standard base excess and acute kidney injury in intensive care unit patients: a study based on the medical information mart for intensive care database.BMC nephrology · 2025Article
- Acidosis as a promising early indicator of mortality among point-of-care parameters and vital signs in non-traumatic critically ill patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Association between cerebrospinal fluid acidosis and cerebral vasospasm and vacuolation following subarachnoid hemorrhage in a rabbit model.Frontiers in neurology · 2025Article
- Association between base excess and mortality in critically ill patients with ischemic stroke: a retrospective cohort study.BMC neurology · 2024Article
- Physiology-Guided Resuscitation: Monitoring and Augmenting Perfusion during Cardiopulmonary Arrest.Journal of clinical medicine · 2024Review
- Determining Predictive Power of Base Excess in Comparison with SOFA Score for Predicting Mortality in ICU Patients.Medical journal of the Islamic Republic of Iran · 2024Article
- Prognostic Significance of the Strong Ion Gap in Patients in Medical and Surgical Intensive Care Units.Cureus · 2023Article
- Serum lactate and the mortality of critically ill patients in the emergency department: A retrospective study.Experimental and therapeutic medicine · 2023Article
- Prognostic factors for patients with hematologic malignancies admitted to the intensive care unit: is allogeneic transplantation still a risk factor?Annals of hematology · 2023Article
- Admission Lactate Concentration, Base Excess, and Alactic Base Excess Predict the 28-Day Inward Mortality in Shock Patients.Journal of clinical medicine · 2022Article
- Higher Total Cholesterol Concentration May Be Associated with Better Cognitive Performance among Elderly Females.Nutrients · 2022Article
- Explainable Machine Learning-Based Risk Prediction Model for In-Hospital Mortality after Continuous Renal Replacement Therapy Initiation.Diagnostics (Basel, Switzerland) · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAs base excess had shown superiority over lactate as a prognostic parameter in intensive care unit (ICU) surgical patients we aimed to evaluate course of lactate, base excess and pH for prediction of mortality of medical ICU patients. MATERIALS AND
methodsFor lactate, pH and base excess, values at the admission to ICU, at 24 ± 4 hours, maximum or minimum in the first 24 hours and in 24-48 hours after admission were collected from all patients admitted to the Medical ICU of the University Hospital Tübingen between January 2016 until December 2018 (N = 4067 at admission, N = 1715 with ICU treatment > 48 h) and investigated for prediction of in-hospital-mortality.
resultsMortality was 22% and significantly correlated with all evaluated parameters. Strongest predictors of mortality determined by ROC were maximum lactate in 24 h (AUROC 0.74, cut off 2.7 mmol/L, hazard ratio of risk group with value > cut off 3.20) and minimum pH in 24 h (AUROC 0.71, cut off 7.31, hazard ratio for risk group 2.94). Kaplan Meier Curves stratified across these cut offs showed early and clear separation. Hazard ratios per standard deviation increase were highest for maximum lactate in 24 h (HR 1.65), minimum base excess in 24 h (HR 1.56) and minimum pH in 24 h (HR 0.75).
conclusionLactate, pH and base excess were all suitable predictors of mortality in internal ICU patients, with maximum / minimum values in 24 and 24-48 h after admission altogether stronger predictors than values at admission. Base excess and pH were not superior to lactate for prediction of mortality.
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