ArticleAnnals of intensive care2021
Awake prone position reduces work of breathing in patients with COVID-19 ARDS supported by CPAP.
Article in Annals of intensive care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05512585 (A Physiological Study to Assess the Effects of Awake Prone Positioning in Healthy Volunteers Under Different Respiratory Support), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Physiological Study to Assess the Effects of Awake Prone Positioning in Healthy Volunteers Under Different Respiratory Support: A Randomized Crossover Study
Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- The effect of prone position on oxygen saturation, blood gas parameters, and respiratory rate in intensive care patients with COVID-19-induced ARDS.Scientific reports · 2025Trial
- Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized controlled trial.European journal of medical research · 2024Trial
- Physiologic effects of prone positioning on gas exchange and ventilation-perfusion matching in awake patients with AHRF.BMC pulmonary medicine · 2024Trial
- Awake pronation with helmet CPAP in early COVID-19 ARDS patients: effects on respiratory effort and distribution of ventilation assessed by EIT.Internal and emergency medicine · 2024Trial
- Lung impedance changes during awake prone positioning in COVID-19. A non-randomized cross-over study.PloS one · 2024Trial
- Physiological effects of awake prone position in acute hypoxemic respiratory failure.Critical care (London, England) · 2023Trial
- Eccentric cycling for chronic respiratory disease: Does helmet ventilation add value? A randomized controlled trial.Chronic respiratory diseaseTrial
- Prone position ventilation combined with high-flow nasal cannula oxygen therapy in patients with pulmonary infection: a retrospective study on evidence-based nursing practice.Frontiers in medicine · 2026Article
- Early physiologic changes after awake prone positioning predict clinical outcomes in patients with acute hypoxemic respiratory failure.Intensive care medicine · 2024Article
- Monitoring and modulation of respiratory drive in patients with acute hypoxemic respiratory failure in spontaneous breathing.Internal and emergency medicine · 2024Review
- Specific and Non-specific Aspects and Future Challenges of ICU Care Among COVID-19 Patients with Obesity: A Narrative Review.Current obesity reports · 2024Review
- Recent advances in cardiorespiratory monitoring in acute respiratory distress syndrome patients.Journal of intensive care · 2024Review
- Oscillometry Longitudinal Data on COVID-19 Acute Respiratory Syndrome Treated with Non-Invasive Respiratory Support.Journal of clinical medicine · 2024Article
- A technique to measure tidal volume during noninvasive respiratory support by continuous-flow helmet CPAP.Journal of clinical monitoring and computing · 2023Article
- Prone Positioning for Patients With COVID-19-Induced Acute Hypoxemic Respiratory Failure: Flipping the Script.Respiratory care · 2023Review
- Personalized noninvasive respiratory support for acute hypoxemic respiratory failure.Intensive care medicine · 2023Article
- Awake prone positioning in acute hypoxaemic respiratory failure.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Mechanical power normalized to aerated lung predicts noninvasive ventilation failure and death and contributes to the benefits of proning in COVID-19 hypoxemic respiratory failure.The EPMA journal · 2023Article
- Effects of an asymmetrical high flow nasal cannula interface in hypoxemic patients.Critical care (London, England) · 2023Article
- Combined Effect of Awake Prone Position and Noninvasive Ventilation on Respiratory Effort and Gas Exchange in Severe COVID-19-Related Pneumonia.Respiratory care · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of awake prone position concomitant to non-invasive mechanical ventilation in acute respiratory distress syndrome (ARDS) secondary to COVID-19 has shown to improve gas exchange, whereas its effect on the work of breathing remain unclear. The objective of this study was to evaluate the effects of awake prone position during helmet continuous positive airway pressure (CPAP) ventilation on inspiratory effort, gas exchange and comfort of breathing.
methodsForty consecutive patients presenting with ARDS due to COVID-19 were prospectively enrolled. Gas exchange, esophageal pressure swing (ΔPes), dynamic transpulmonary pressure (dTPP), modified pressure time product (mPTP), work of breathing (WOB) and comfort of breathing, were recorded on supine position and after 3 h on prone position.
resultsThe median applied PEEP with helmet CPAP was 10 [8-10] cmH
conclusionsAwake prone position with helmet CPAP enables a reduction in the work of breathing and an improvement in oxygenation in COVID-19-associated ARDS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.