ArticleEuropean radiology2022
Visualization of the saccule and utricle with non-contrast-enhanced FLAIR sequences.
Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 16 citations in OpenAlex.
- Enabling unenhanced endolymphatic hydrops MRI: a subtraction method using 3D-FLAIR sequences with different inversion time.European radiology · 2026Article
- Reply to: Hyperintense FLAIR signal in the anterior cranial fossa.Nature communications · 2026Article
- Substantially Higher Vestibular Hydrops Agreement in Older Patients Assessed by Non-contrast vs. Contrast-enhanced MRI: A Preliminary Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Age-related development of meningeal lymphatic vessels in children assessed by 3D T2 FLAIR MRI.Scientific reports · 2026Article
- Labyrinthine Signal Intensity on Non-contrast-enhanced 3D-real Inversion Recovery MR Imaging: Correlation with the Endolymphatic Volume Measured on Contrast-enhanced HYDROPS-Mi2.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Optimized 3D-ZOOMit real IR combined with T2-preparation improves perilymphatic enhancement and endolymphatic hydrops detection.Neuroradiology · 2026Article
- Combining optimized three-dimensional ZOOMit real inversion recovery with T2-preparation to shorten the delay interval and scan time for endolymphatic hydrops evaluation in patients with Ménière's disease.Quantitative imaging in medicine and surgery · 2025Article
- Preliminary Findings on Non-contrast Enhanced Positive Endolymph Images: Limited Delineation of Endolymphatic Space.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- The Endolymph Signal in Non-contrast Enhanced 3D-real IR Image Differs between the Ears with and without Significant Endolymphatic Hydrops.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- An unenhanced 3D-FLAIR sequence using long repetition time and constant flip angle to image endolymphatic hydrops.European radiology · 2025Article
- Effect of the Surrounding Magnetic Environment of Temporal Bone on the Fluid Signal Intensity in Human Inner Ear Using a Combined T2 Preparation Pulse and Fluid Attenuated Inversion Pulse Technique.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Article
- New non-contrast MRI of endolymphatic hydrops in Ménière's disease considering inversion time.Laryngoscope investigative otolaryngology · 2024Article
- Reply to: Fluid signal suppression characteristics of 3D-FLAIR with a T2 selective inversion pulse in the skull base.Nature communications · 2023Article
- Pitfalls of Using T2-contrast Enhancement Techniques in 3D-FLAIR to Detect Endolymphatic Hydrops.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Article
- Longitudinal variation of endolymphatic hydrops in patients with Ménière's disease.Annals of translational medicine · 2023Article
- Editorial: Hydropic Ear Disease: Imaging and Functional Evaluation.Frontiers in surgery · 2022Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectives3D-fluid attenuation inversion recovery (FLAIR) collected 4 h after intravenous gadolinium injection can delineate the perilymphatic space (PLS) from the endolymphatic space (ELS) to capture endolymphatic hydrops, the pathological counterpart of Ménière's disease. We aimed to optimize visualization of such inner ear internal anatomy using 3D-FLAIR without injection.
methods3D-FLAIR signal from different fluid compartments such as PLS and ELS was first simulated. Then, twenty-two healthy subjects were scanned at 3.0-T MRI with non-injected 3D-FLAIR using variable T2 preparations (T2Preps) (OFF, 200, 400, and 600 ms) and variable inversion times (TIs) (from 224 to 5000 ms) and different resolutions (1.0 × 1.0 × 1.5, 0.6 × 0.6 × 0.8, and 0.6 × 0.6 × 0.6 mm
resultsThe PLS and ELS were differentiated when T2Prep was used but not without. The relative contrast was larger with T2Prep at 400 ms than at 200 or 600 ms (0.72 ± 0.22 vs. 0.44 ± 0.11, p = 0.019; and 0.72 ± 0.22 vs. 0.46 ± 0.28, p = 0.034, respectively). The saccule and utricle were best delineated in 87. % cases with T2Prep = 400 and TI = 2100 ms at the highest resolution. Visualization of the saccule and utricle in the optimized non-injected 3D-FLAIR was similar to conventional injected 3D-FLAIR in a patient.
conclusionsCombining a specific T2Prep and TI in non-injected 3D-FLAIR could separate PLS and ELS and even the saccule and utricle, paving the way toward future application to diagnose Ménière's disease. KEY POINTS: • MRI can capture the internal anatomy of inner ear without injection of contrast media. • Specific parameters consisting of a T2 preparation of 400 ms and an inversion time of 2100 ms must be used to visualize the saccule and utricle on non-injected 3D-FLAIR.
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