Evidence map›Paper›PMID 34928408›Full record

Trial reportEuropean journal of nutrition2022

A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults.

Camila L P Oliveira, Normand G Boulé, Sarah A Elliott, Arya M Sharma, Mario Siervo, Aloys Berg, Sunita Ghosh, Carla M Prado

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02811276 nacompletednot on this map

A Randomized, Controlled, Cross-over Trial Investigating the Impact of a High Protein Diet on Substrate Oxidation and Energy Metabolism in Healthy Women

TypeinterventionalSponsorUniversity of AlbertaRan2016 to 2018Enrolled20ConditionsDietary ModificationArmsDiet
NCT03565510 nacompletednot on this map

A Randomized, Controlled, Cross-over Trial Investigating the Impact of a High-protein Diet on Energy Metabolism in Healthy Men

TypeinterventionalSponsorUniversity of AlbertaRan2018 to 2019Enrolled27ConditionsDietary ModificationArmsHigh-Protein Diet
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Camila L P OliveiraHuman Nutrition Research Unit, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Normand G BouléAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Sarah A ElliottHuman Nutrition Research Unit, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Arya M SharmaDivision of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Mario SiervoSchool of Life Sciences, Division of Physiology, Pharmacology and Neuroscience, University of Nottingham, Nottingham, England, UK.
Aloys BergFaculty of Medicine, University of Freiburg, Freiburg, Germany.
Sunita GhoshDepartment of Medical Oncology, University of Alberta, Edmonton, AB, Canada.
Carla M PradoHuman Nutrition Research Unit, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada. cprado@ualberta.ca.
University of Alberta · CAUniversity of Freiburg · DEUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDietary intake can affect energy homeostasis and influence body weight control. The aim of this study was to compare the impact of high-protein total diet replacement (HP-TDR) versus a control (CON) diet in the regulation of food intake and energy homeostasis in healthy, normal-weight adults.

methodsIn this acute randomized controlled, cross-over study, participants completed two isocaloric arms: a) HP-TDR: 35% carbohydrate, 40% protein, and 25% fat; b) CON: 55% carbohydrate, 15% protein, and 30% fat. The diets were provided for 32 h while inside a whole-body calorimetry unit. Appetite sensations, appetite-related hormones, and energy metabolism were assessed.

resultsForty-three healthy, normal-weight adults (19 females) participated. Appetite sensations did not differ between diets (all p > 0.05). Compared to the CON diet, the change in fasting blood markers during the HP-TDR intervention was smaller for peptide tyrosine-tyrosine (PYY; - 18.9 ± 7.9 pg/mL, p = 0.02) and greater for leptin (1859 ± 652 pg/mL, p = 0.007). Moreover, postprandial levels of glucagon-like peptide 1 (1.62 ± 0.36 pM, p < 0.001) and PYY (31.37 ± 8.05 pg/mL, p < 0.001) were higher in the HP-TDR. Significant correlations were observed between energy balance and satiety (r = - 0.41, p = 0.007), and energy balance and PFC (r = 0.33, p = 0.033) in the HP-TDR.

conclusionCompared to the CON diet, the HP-TDR increased blood levels of anorexigenic hormones. Moreover, females and males responded differently to the intervention in terms of appetite sensations and appetite-related hormones.

trial registrationNCT02811276 (retrospectively registered on 16 June 2016) and NCT03565510 (retrospectively registered on 11 June 2018).

Indexed as

AppetiteEnergy IntakeAdultCarbohydratesCross-Over StudiesDietEatingEnergy MetabolismFemaleGhrelinHomeostasisHumansMalePeptide YYCarbohydratesGhrelinPeptide YYAppetiteAppetite-related hormonesEnergy homeostasisProteinTotal diet replacement

Identifiers

PMID34928408
PMCPMC9106637
OpenAlexW4200254527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.