ArticleJAMA network open2021
Exploration of Cognitive Outcomes and Risk Factors for Cognitive Decline Shared by Couples.
Article in JAMA network open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Domain-Specific Cognitive Concordance in Older Married Couples.JAMA network open · 2026Article
- Spousal Dementia Exposure and Risk of Dementia.JAMA network open · 2026Article
- Complex atypical caregiving: navigating the margins of unique caregiver roles and burdens.Frontiers in psychology · 2026Article
- Refining Western Dementia-Risk Paradigms: Evidence From a Decade of the Korean Longitudinal Study on Cognitive Aging and Dementia.Journal of Korean medical science · 2025Review
- Linked Lives: Dyadic Trajectories of Cognitive Function Among Middle-Aged and Older Couples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Review
- Long-term risk of late-life depression in widowed elderly: a five-year follow-up study.BMC geriatrics · 2025Article
- Striking a balance: health behaviour changes in Chinese spouses of people with dementia to manage dementia risk: a qualitative study.BMC nursing · 2024Article
- Facial aging, cognitive impairment, and dementia risk.Alzheimer's research & therapy · 2024Article
- Effects of Cohabitation on Neurodevelopmental Outcomes in Rats Discordant for Neonatal Exposure to Sevoflurane.Biological psychiatry global open science · 2024Article
- Masticatory Function, Sex, and Risk of Dementia Among Older Adults: A Population-Based Cohort Study.Journal of Korean medical science · 2024Article
- The Longitudinal Dyadic Associations Between Social Participation and Cognitive Function in Older Chinese Couples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Article
- The Association of Neighborhood Socioeconomic Status with Executive Function and Processing Speed in Cognitively Normal Mexican American Elders from the Health and Aging Brains Study: Health Disparities Cohort.Dementia and geriatric cognitive disorders · 2024Article
- Article
- What is the impact of one's chronic illness on his or her spouse's future chronic illness: a community-based prospective cohort study.BMC medicine · 2023Article
- Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea.JAMA network open · 2023Article
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Authors and funding
19 authors at 13 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Importance: Although couples could share many risk factors of cognitive disorders in their lifetime, whether shared risk factors mediate the shared risk of cognitive disorders has rarely been investigated. Objective: To identify the risk factors of cognitive decline shared within couples and investigate their mediating roles in the shared risk of cognitive disorders and cognitive functions within couples. Design, Setting, and Participants: A prospective cohort study was launched in November 1, 2010, and 784 participants were followed up every 2 years until December 31, 2020. This nationwide, multicenter, community-based study included older couples from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) and a cohort of their spouses (KLOSCAD-S). Exposures: The cognitive disorder of a spouse was defined as mild cognitive impairment or dementia. Main Outcomes and Measures: The mediating roles of factors shared within couples on the association between one spouse's cognitive disorder and the other's risk of cognitive disorders was examined with structural equation modeling. Results: Included were 784 KLOSCAD participants (307 women [39.2%] and 477 men [60.8%]; mean [SD] age, 74.8 [4.8] years) and their spouses (477 women [60.8%] and 307 men [39.2%]; mean [SD] age, 73.6 [6.2] years). The cognitive disorder of the KLOSCAD participants was associated with almost double the risk of cognitive disorder of their spouses in the KLOSCAD-S cohort (odds ratio, 1.74; 95% CI, 1.12-2.69; P = .01). History of head injury (β = 0.50; 95% CI, 0.09-0.90; P = .02) and age (β = 2.57; 95% CI, 1.37-3.76; P < .001) mediated the association between cognitive disorder in the KLOSCAD participants and their spouses' risk of cognitive disorder. Physical inactivity mediated the association through major depressive disorder (β = 0.33, 95% CI, 0.09-0.57, P = .006 for physical inactivity; β = 0.28, 95% CI, 0.13-0.44, P < .001 for major depressive disorder). These factors similarly mediated the association between spousal cognitive disorder and cognitive functions such as memory and executive function. Conclusions and Relevance: These findings suggest that the risk factors shared within couples may mediate approximately three-quarters of the spousal risk of cognitive disorders. Identification of and intervention in the shared risk factors of dementia within couples may reduce the risk of cognitive disorders in the spouses of people with dementia.
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