Evidence map›Paper›PMID 34928350›Full record

ArticleThe Journal of nutrition2022

The Total Nutrient Index is a Useful Measure for Assessing Total Micronutrient Exposures Among US Adults.

Alexandra E Cowan, Regan L Bailey, Shinyoung Jun, Kevin W Dodd, Jaime J Gahche, Heather A Eicher-Miller, Patricia M Guenther, Johanna T Dwyer, Nancy Potischman, Anindya Bhadra and 2 more

Abstract read
In one paragraph

Article in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra E CowanDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-2544-2676
Regan L BaileyDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-0181-6223
Shinyoung JunDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-2452-4709
Kevin W DoddNIH National Cancer Institute, Bethesda, MD, USA.
Jaime J GahcheNIH Office of Dietary Supplements, Bethesda, MD, USA.
Heather A Eicher-MillerDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-1261-4291
Patricia M GuentherDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Johanna T DwyerNIH Office of Dietary Supplements, Bethesda, MD, USA.ORCID 0000-0002-0783-1769
Nancy PotischmanNIH Office of Dietary Supplements, Bethesda, MD, USA.
Anindya BhadraDepartment of Statistics, Purdue University, West Lafayette, IN, USA.
Raymond J CarrollDepartment of Statistics, Texas A&M University, College Station, TX, USA.
Janet A ToozeWake Forest School of Medicine, Winston-Salem, NC, USA.

Funding

Development of a Total Nutrient IndexU01CA215834 · NCI · TEXAS A&M AGRILIFE RESEARCH · PI REGAN BAILEY, JANET A. TOOZE · 2017 to 2026
$2.2M
NCI NIH HHS U01 CA215834
6 · The paper itself

Abstract

backgroundMost dietary indices reflect foods and beverages and do not include exposures from dietary supplements (DS) that provide substantial amounts of micronutrients. A nutrient-based approach that captures total intake inclusive of DS can strengthen exposure assessment.

objectivesWe examined the construct and criterion validity of the Total Nutrient Index (TNI) among US adults (≥19 years; nonpregnant or lactating).

methodsThe TNI includes 8 underconsumed micronutrients identified by the Dietary Guidelines for Americans: calcium; magnesium; potassium; choline; and vitamins A, C, D, and E. The TNI is expressed as a percentage of the RDA or Adequate Intake to compute micronutrient component scores; the mean of the component scores yields the TNI score, ranging from 0-100. Data from exemplary menus and the 2003-2006 (≥19 years; n = 8861) and 2011-2014 NHANES (≥19 years; n = 9954) were employed. Exemplary menus were used to determine whether the TNI yielded high scores from dietary sources (women, 31-50 years; men ≥ 70 years). TNI scores were correlated with Healthy Eating Index (HEI) 2015 overall and component scores for dairy, fruits, and vegetables; TNI component scores for vitamins A, C, D, and E were correlated with respective biomarker data. TNI scores were compared between groups with known differences in nutrient intake based on the literature.

resultsThe TNI yielded high scores on exemplary menus (84.8-93.3/100) and was moderately correlated (r = 0.48) with the HEI-2015. Mean TNI scores were significantly different for DS users (83.5) compared with nonusers (67.1); nonsmokers (76.8) compared with smokers (70.3); and those living with food security (76.6) compared with food insecurity (69.1). Correlations of TNI vitamin component scores with available biomarkers ranged from 0.12 (α-tocopherol) to 0.36 (serum 25-hydroxyvitamin D), and were significantly higher than correlations obtained from the diet alone.

conclusionsThe evaluation of validity supports that the TNI is a useful construct to assess total micronutrient exposures of underconsumed micronutrients among US adults.

Indexed as

MicronutrientsTrace ElementsAdultDietDietary SupplementsFemaleHumansLactationMaleNutrientsNutrition SurveysUnited StatesVitamin AVitaminsMicronutrientsNutrientsTrace ElementsVitamin AVitaminsdietary supplementdiet qualitytotal nutrient indextotal usual intake estimationvalidity

Identifiers

PMID34928350
PMCPMC8891182

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.