Evidence map›Paper›PMID 34928336›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2022

Effects of Vitamin D on Physical Function: Results From the STURDY Trial.

Jack M Guralnik, Alice L Sternberg, Christine M Mitchell, Amanda L Blackford, Jennifer Schrack, Amal A Wanigatunga, Erin Michos, Stephen P Juraschek, Sarah Szanton, Rita Kalyani and 3 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02166333 (Vitamin D Supplements to Prevent Falls in Older Adults), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02166333 naterminatednot on this map

Vitamin D Supplements to Prevent Falls in Older Adults: A Dose-Response Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2015 to 2019Enrolled688ConditionsVitamin D Deficiency, FallsArms200 IU/d cholecalciferol, 1000 IU/d cholecalciferol, 2000 IU/d cholecalciferol, 4000 IU/d cholecalciferol
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jack M GuralnikDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Alice L SternbergDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Christine M MitchellDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Amanda L BlackfordOncology Biostatistics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6519-4833
Jennifer SchrackDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-9244-9267
Amal A WanigatungaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-5763-5184
Erin MichosDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5547-5084
Stephen P JuraschekDivision of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID 0000-0003-4168-2696
Sarah SzantonSchool of Nursing, Johns Hopkins University, Baltimore, Maryland, USA.
Rita KalyaniDivision of Endocrinology, Diabetes, & Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1530-6884
Yurun CaiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-8264-8158
Lawrence J AppelWelch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University , Baltimore, Maryland, USA.
STURDY Collaborative Research Group
Johns Hopkins University · USBeth Israel Deaconess Medical Center · USUniversity of Maryland, Baltimore · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
Vitamin D Supplements to Prevent Falls in Older Adults: A Dose-Response TrialU01AG047837 · NIA · JOHNS HOPKINS UNIVERSITY · PI APPEL, LAWRENCE JOHN · 2014 to 2019
$9.5M
RENAL DISEASE EPIDEMIOLOGY TRAINING GRANTT32DK007732 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CREWS, DEIDRA CANDICE · 1995 to 2024
$7.7M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
Glucose Insulin and Muscle LossK23DK093583 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KALYANI, RITA R · 2012 to 2015
$635k
Energy Expenditure, Activity, and Aging With HIV:Effects on Functional LongevityK01AG048765 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHRACK, JENNIFER ANN · 2014 to 2016
$388k
NCATS NIH HHS UL1 TR003098NHLBI NIH HHS K23 HL135273NIA NIH HHS K01 AG048765NIA NIH HHS U01 AG047837NIDDK NIH HHS K23 DK093583NIDDK NIH HHS P30 DK072488NIDDK NIH HHS T32 DK007732
6 · The paper itself

Abstract

backgroundStudies of the relationship between vitamin D and physical functioning have had inconsistent results.

methodsPhysical functioning measures were collected for up to 2 years during a 2-stage, Bayesian, response-adaptive, randomized trial of 4 doses of vitamin D3 supplementation (200 [control], 1 000, 2 000, and 4 000 IU/day) to prevent falls. Two community-based research units enrolled adults aged ≥70 years, with elevated fall risk and serum 25-hydroxyvitamin D level of 10-29 ng/mL. The Pooled Higher Doses (PHD) group (≥1 000 IU/day, n = 349) was compared to the control group (n = 339) on changes in Short Physical Performance Battery (SPPB) score and its component tests, Timed Up-and-Go (TUG) test, 6-minute walk distance, and grip strength.

resultsThe trial enrolled 688 participants. Mean age was 77.2 years, 56.4% were male, 79.7% White, and 18.2% Black. While the PHD and control groups both lost function over time on most outcomes, the 2 groups did not show differential change overall on any outcome. Incidence of transitioning to poor functioning on gait speed, SPPB score, or TUG test did not differ by dose group.

conclusionIn older persons with low serum 25-hydroxyvitamin D level and elevated fall risk, high-dose vitamin D supplementation, ≥1 000 IU/day, did not improve measures of physical function compared to 200 IU/day. CLINICAL

trial registrationNCT02166333.

Indexed as

Vitamin DVitaminsAgedAged, 80 and overBayes TheoremCholecalciferolDietary SupplementsDouble-Blind MethodFemaleHand StrengthHumansMaleCholecalciferolVitamin DVitaminsPhysical functioningRandomized controlled trialVitamin D

Identifiers

PMID34928336
PMCPMC9373949
OpenAlexW4200078442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.