Evidence map›Paper›PMID 34928136›Full record

ReviewChemical reviews2022

Free Energies of Proton-Coupled Electron Transfer Reagents and Their Applications.

Rishi G Agarwal, Scott C Coste, Benjamin D Groff, Abigail M Heuer, Hyunho Noh, Giovanny A Parada, Catherine F Wise, Eva M Nichols, Jeffrey J Warren, James M Mayer

Abstract readReview
In one paragraph

Review in Chemical reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed.

  1. Cross-Dehydrogenative Coupling Reactions With Redox-Active Guanidine Reagents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Beyond the Oxo-Wall: Synthesis and Reactivity of a Six-Coordinate Formally CoAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Net fluorine atom transfer from the perspective of a PCET chemist.Chemical communications (Cambridge, England) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
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  11. Article
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  15. Unveiling the Potential ofJournal of the American Chemical Society · 2026
    Article
  16. Mimicking Extradiol Dioxygenase Reactivity on Iridium.Journal of the American Chemical Society · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rishi G AgarwalDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-5133-0136
Scott C CosteDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Benjamin D GroffDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Abigail M HeuerDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Hyunho NohDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0003-3136-1004
Giovanny A ParadaDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Catherine F WiseDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-9947-7700
Eva M NicholsDepartment of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.ORCID 0000-0002-3718-7273
Jeffrey J WarrenDepartment of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0002-1747-3029
James M MayerDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-3943-5250

Funding

UNDERSTANDING METAL MEDIATED C-H AND O-H BOND OXIDATIONSR01GM050422 · NIGMS · YALE UNIVERSITY · PI MAYER, JAMES M · 1995 to 2020
$6.1M
Model Systems for C-H Bond Transformations through Multiple-Site Concerted Proton-Electron TransferF32GM139266 · NIGMS · YALE UNIVERSITY · PI COSTE, SCOTT CHRISTOPHER · 2020 to 2022
$189k
Model Systems for the Elucidation of Parameters Governing Electron BifurcationF32GM129902 · NIGMS · YALE UNIVERSITY · PI NICHOLS, EVA MEGAN · 2018 to 2019
$114k
NIGMS NIH HHS F32 GM129902NIGMS NIH HHS F32 GM139266NIGMS NIH HHS R01 GM050422
6 · The paper itself

Abstract

We present an update and revision to our 2010 review on the topic of proton-coupled electron transfer (PCET) reagent thermochemistry. Over the past decade, the data and thermochemical formalisms presented in that review have been of value to multiple fields. Concurrently, there have been advances in the thermochemical cycles and experimental methods used to measure these values. This Review (i) summarizes those advancements, (ii) corrects systematic errors in our prior review that shifted many of the absolute values in the tabulated data, (iii) provides updated tables of thermochemical values, and (iv) discusses new conclusions and opportunities from the assembled data and associated techniques. We advocate for updated thermochemical cycles that provide greater clarity and reduce experimental barriers to the calculation and measurement of Gibbs free energies for the conversion of X to XH

Indexed as

ElectronsProtonsElectron TransportIndicators and ReagentsIndicators and ReagentsProtons

Identifiers

PMID34928136
PMCPMC9175307

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.