Evidence map›Paper›PMID 34927972›Full record

ArticleSmall methods2021

Superferromagnetic Nanoparticles Enable Order-of-Magnitude Resolution & Sensitivity Gain in Magnetic Particle Imaging.

Zhi Wei Tay, Shehaab Savliwala, Daniel W Hensley, K L Barry Fung, Caylin Colson, Benjamin D Fellows, Xinyi Zhou, Quincy Huynh, Yao Lu, Bo Zheng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  16. Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhi Wei TayDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.ORCID 0000-0002-2717-0515
Shehaab SavliwalaDepartment of Chemical Engineering, University of Florida, Gainesville, FL, 32611-6005, USA.ORCID 0000-0002-9060-5737
Daniel W HensleyDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.
K L Barry FungDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.ORCID 0000-0002-7925-8033
Caylin ColsonDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.
Benjamin D FellowsDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.ORCID 0000-0002-8404-7281
Xinyi ZhouDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.
Quincy HuynhDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.ORCID 0000-0002-6725-3999
Yao LuDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.
Bo ZhengDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.
Prashant ChandrasekharanDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.ORCID 0000-0002-6139-1979
Sindia M Rivera-JimenezDepartment of Chemical Engineering, University of Florida, Gainesville, FL, 32611-6005, USA.
Carlos M Rinaldi-RamosDepartment of Chemical Engineering, University of Florida, Gainesville, FL, 32611-6005, USA.ORCID 0000-0001-8886-5612
Steven M ConollyDepartment of Bioengineering, 340 Hearst Memorial Mining Building, University of California Berkeley, Berkeley, CA, 94720-1762, USA.

Funding

Ten-Fold Resolution Boost for Magnetic Particle Imaging with Applications to Rapid, Non-Invasive Imaging of CAR-T Cell Therapies, Stroke, GI Bleeds and Pulmonary EmbolismsU01EB034694 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI STEVEN M CONOLLY · 2023 to 2026
$2.7M
In Vivo Therapeutic Cell Tracking by Advanced Magnetic Particle ImagingR01EB024578 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2017 to 2020
$2.2M
Pre-clinical quantitation of ovarian cancer tumor burden using Magnetic Particle Imaging and non-dilutive cell labelingR01EB019458 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI BELL, CALEB B., CONOLLY, STEVEN M · 2015 to 2018
$1.9M
Color MPI as a novel method for in vivo assessment of magnetic nanoparticle dynamics and bindingR44EB029877 · NIBIB · MAGNETIC INSIGHT, INC. · PI GOODWILL, PATRICK · 2020 to 2021
$1.6M
Magnetic Particle Imaging for High-Resolution Functional Brain ImagingR01EB029822 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONOLLY, STEVEN M · 2020 to 2020
$815k
Modeling of the Magnetic Particle Imaging Signal Due to Magnetic NanoparticlesR21EB018453 · NIBIB · UNIVERSITY OF FLORIDA · PI RINALDI-RAMOS, CARLOS M · 2015 to 2016
$387k
Agency of Science Technology and Research (A*STAR) Singapore BMRC Central Research Fund 202D800036NIBIB NIH HHS R01 EB019458NIBIB NIH HHS R01 EB024578NIBIB NIH HHS R01 EB029822NIBIB NIH HHS R21 EB018453NIBIB NIH HHS R44 EB029877NIBIB NIH HHS U01 EB034694Siebel Scholars FoundationUniversity of Florida NIH 1R21 EB018453-01A1University of Florida Health Cancer Center
6 · The paper itself

Abstract

Magnetic nanoparticles have many advantages in medicine such as their use in non-invasive imaging as a Magnetic Particle Imaging (MPI) tracer or Magnetic Resonance Imaging contrast agent, the ability to be externally shifted or actuated and externally excited to generate heat or release drugs for therapy. Existing nanoparticles have a gentle sigmoidal magnetization response that limits resolution and sensitivity. Here it is shown that superferromagnetic iron oxide nanoparticle chains (SFMIOs) achieve an ideal step-like magnetization response to improve both image resolution & SNR by more than tenfold over conventional MPI. The underlying mechanism relies on dynamic magnetization with square-like hysteresis loops in response to 20 kHz, 15 kAm

Indexed as

Cells, CulturedHumansMagnetic Resonance ImagingMagnetite NanoparticlesMesenchymal Stem CellsMagnetite Nanoparticlesmagnetic nanoparticlesmagnetic particle imagingsuperferromagnetism

Identifiers

PMID34927972
PMCPMC8837195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.