Evidence map›Paper›PMID 34927583›Full record

ArticleeLife2021

Building a community to engineer synthetic cells and organelles from the bottom-up.

Oskar Staufer, Jacqueline A De Lora, Eleonora Bailoni, Alisina Bazrafshan, Amelie S Benk, Kevin Jahnke, Zachary A Manzer, Lado Otrin, Telmo Díez Pérez, Judee Sharon and 12 more

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. A synthetic cell phage cycle.Nature communications · 2025
    Article
  5. Building a Synthetic Cell Together.Nature communications · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Present and future of synthetic cell development.Nature reviews. Molecular cell biology · 2024
    Article
  10. Review
  11. Formation of Giant Unilamellar Vesicles Assisted by Fluorinated Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Light energy transduction in liposome-based artificial cells.Frontiers in bioengineering and biotechnology · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Oskar StauferMax Planck Institute for Medical Research, Heidelberg, Germany.ORCID 0000-0002-8015-3132
Jacqueline A De LoraMax Planck Institute for Medical Research, Heidelberg, Germany.ORCID 0000-0001-5599-7838
Eleonora BailoniUniversity of Groningen, Groningen, Netherlands.
Alisina BazrafshanEmory University, Atlanta, United States.ORCID 0000-0002-3259-8196
Amelie S BenkMax Planck Institute for Medical Research, Heidelberg, Germany.
Kevin JahnkeMax Planck Institute for Medical Research, Heidelberg, Germany.ORCID 0000-0001-7311-6993
Zachary A ManzerCornell University, Ithaca, United States.ORCID 0000-0002-8225-8990
Lado OtrinMax Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany.ORCID 0000-0001-5862-456X
Telmo Díez PérezUniversity of New Mexico, Albuquerque, United States.
Judee SharonUniversity of Minnesota, Minneapolis, United States.ORCID 0000-0001-5691-0407
Jan SteinkühlerNorthwestern University, Evanston, United States.ORCID 0000-0003-4226-7945
Katarzyna P AdamalaUniversity of Minnesota, Minneapolis, United States.ORCID 0000-0003-1066-7207
Bruna JacobsonUniversity of New Mexico, Albuquerque, United States.
Marileen DogteromBaSyC Consortium, Delft, Netherlands.ORCID 0000-0002-8803-5261
Kerstin GöpfrichMax Planck Institute for Medical Research, Heidelberg, Germany.ORCID 0000-0003-2115-3551
Darko StefanovicUniversity of New Mexico, Albuquerque, United States.
Susan R AtlasUniversity of New Mexico, Albuquerque, United States.ORCID 0000-0003-1542-2700
Michael GrunzeMax Planck Institute for Medical Research, Heidelberg, Germany.ORCID 0000-0002-2335-9513
Matthew R LakinUniversity of New Mexico, Albuquerque, United States.
Andrew P ShreveUniversity of New Mexico, Albuquerque, United States.ORCID 0000-0002-9567-3181
Joachim P SpatzMax Planck Institute for Medical Research, Heidelberg, Germany.ORCID 0000-0003-3419-9807
Gabriel P LópezUniversity of New Mexico, Albuquerque, United States.ORCID 0000-0002-5383-0708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Employing concepts from physics, chemistry and bioengineering, 'learning-by-building' approaches are becoming increasingly popular in the life sciences, especially with researchers who are attempting to engineer cellular life from scratch. The SynCell2020/21 conference brought together researchers from different disciplines to highlight progress in this field, including areas where synthetic cells are having socioeconomic and technological impact. Conference participants also identified the challenges involved in designing, manipulating and creating synthetic cells with hierarchical organization and function. A key conclusion is the need to build an international and interdisciplinary research community through enhanced communication, resource-sharing, and educational initiatives.

Indexed as

Artificial CellsIntersectoral CollaborationBioengineeringForecastingHumansOrganellesSynthetic Biologycommunity buildingmolecular biophysicsnonestructural biologySynCellsynthetic biology

Identifiers

PMID34927583
PMCPMC8716100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.