Evidence map›Paper›PMID 34927446›Full record

ArticleJournal of the American Heart Association2022

Non-Hispanic Black and Hispanic Patients Have Worse Outcomes Than White Patients Within Similar Stages of Peripheral Artery Disease.

Corey A Kalbaugh, Brian Witrick, Laksika Banu Sivaraj, Katharine L McGinigle, Catherine R Lesko, Samuel Cykert, William P Robinson

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
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  5. Racial and Socioeconomic Health Disparities in Peripheral Artery Disease.Journal of the American Heart Association · 2024
    Review
  6. Investigating Unconscious Race Bias and Bias Awareness Among Vascular Surgeons.medRxiv : the preprint server for health sciences · 2024
    Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Corey A KalbaughDepartment of Public Health Sciences Clemson University Clemson SC.
Brian WitrickDepartment of Public Health Sciences Clemson University Clemson SC.
Laksika Banu SivarajDepartment of Public Health Sciences Clemson University Clemson SC.ORCID 0000-0002-7214-5597
Katharine L McGinigleDepartment of Surgery School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC.
Catherine R LeskoDepartment of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD.ORCID 0000-0002-1717-2592
Samuel CykertDepartment of Internal Medicine School of Medicine The University of North Carolina at Chapel Hill Chapel Hill NC.ORCID 0000-0003-2037-6809
William P RobinsonDivision of Vascular Surgery Southern Illinois University School of Medicine Springfield IL.ORCID 0000-0002-0150-0758
Clemson University · USUniversity of North Carolina at Chapel Hill · USJohns Hopkins University · USSouthern Illinois University School of Medicine · US

Funding

Unhealthy alcohol use, other drug use, and mental health disorders: comorbidity burden in people with HIV, gaps in treatment, and impact on the HIV care continuumK01AA028193 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI LESKO, CATHERINE · 2019 to 2023
$900k
Understanding and Addressing Racial Disparities in Guideline-Indicated Management of Symptomatic Peripheral Artery DiseaseK01HL146900 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI KALBAUGH, COREY ANDREW · 2020 to 2024
$680k
NHLBI NIH HHS K01 HL146900NIAAA NIH HHS K01 AA028193
6 · The paper itself

Abstract

Background Racial and ethnic disparities in outcomes following lower limb revascularization for peripheral artery disease have been ascribed to disease severity at presentation for surgery. Methods and Results We calculated 1-year risk of major adverse limb events (MALEs), major amputation, and death for patients undergoing elective revascularization for claudication or chronic limb-threatening ischemia in the Vascular Quality Initiative data (2011-2018). We report hazard ratios according to race and ethnicity using Cox (death) or Fine and Gray subdistribution hazards models (MALE and major amputation, treating death as a competing event), adjusted for patient, treatment, and anatomic factors associated with disease severity. Among 88 599 patients (age, 69 years; 37% women), 1-year risk of MALE (major amputation and death) was 12.8% (95% CI, 12.5-13.0) in 67 651 White patients, 16.5% (95% CI, 5.8-7.8) in 15 442 Black patients, and 17.2% (95% CI, 5.6-6.9) in 5506 Hispanic patients. Compared with White patients, we observed an increased hazard of poor limb outcomes among Black (MALE: 1.17; 95% CI, 1.12-1.22; amputation: 1.52; 95% CI, 1.39-1.65) and Hispanic (MALE: 1.22; 95% CI, 1.14-1.31; amputation: 1.45; 95% CI, 1.28-1.64) patients. However, Black and Hispanic patients had a hazard of death of 0.85 (95% CI, 0.79-0.91) and 0.71 (95% CI, 0.63-0.79) times the hazard among White patients, respectively. Worse limb outcomes were observed among Black and Hispanic patients across subcohorts of claudication and chronic limb-threatening ischemia. Conclusions Black and Hispanic patients undergoing infrainguinal revascularization for chronic limb-threatening ischemia and claudication had worse limb outcomes compared with White patients, even with similar disease severity at presentation. Additional investigation aimed at eliminating disparate limb outcomes is needed.

Indexed as

Limb SalvagePeripheral Arterial DiseaseAgedAmputation, SurgicalFemaleHumansIntermittent ClaudicationIschemiaLower ExtremityMaleRetrospective StudiesRisk FactorsTreatment OutcomeamputationBlack patientsethnic groupsfemale sexhumansintermittent claudicationperipheral artery disease

Identifiers

PMID34927446
PMCPMC9075215
OpenAlexW4200333900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.