Evidence map›Paper›PMID 34927381›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation.

Yichao Yu, Christopher Payne, Nephtali Marina, Alla Korsak, Paul Southern, Ana García-Prieto, Isabel N Christie, Rebecca R Baker, Elizabeth M C Fisher, Jack A Wells and 4 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Article
  9. Magnetoelectric nanoparticles shape modulates their electrical output.Frontiers in bioengineering and biotechnology · 2023
    Article
  10. Review
  11. Review
  12. Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Yichao YuCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, 72 Huntley Street, London, WC1E 6DD, UK.ORCID 0000-0003-1838-6688
Christopher PayneCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
Nephtali MarinaCentre for Cardiovascular and Metabolic Neuroscience, Research Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Alla KorsakCentre for Cardiovascular and Metabolic Neuroscience, Research Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Paul SouthernHealthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK.
Ana García-PrietoHealthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK.
Isabel N ChristieCentre for Cardiovascular and Metabolic Neuroscience, Research Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Rebecca R BakerCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
Elizabeth M C FisherDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Jack A WellsCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
Tammy L KalberCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
Quentin A PankhurstHealthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK.
Alexander V GourineCentre for Cardiovascular and Metabolic Neuroscience, Research Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
Mark F LythgoeCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
University College London · GBAlbemarle (United States) · USQueen Mary University of London · GB

Funding

Cancer Research UK C1519/A10331Cancer Research UK C1519/A16463Cancer Research UK C7893/A27590Medical Research Council MR/J013110/1Wellcome Trust 200893Wellcome Trust 200893/Z/16/ZWellcome Trust 204624/Z/16/Z
6 · The paper itself

Abstract

Astrocytes play crucial and diverse roles in brain health and disease. The ability to selectively control astrocytes provides a valuable tool for understanding their function and has the therapeutic potential to correct dysfunction. Existing technologies such as optogenetics and chemogenetics require the introduction of foreign proteins, which adds a layer of complication and hinders their clinical translation. A novel technique, magnetomechanical stimulation (MMS), that enables remote and selective control of astrocytes without genetic modification is described here. MMS exploits the mechanosensitivity of astrocytes and triggers mechanogated Ca

Indexed as

Magnetic FieldsAnimalsAstrocytesBrainBrain StemCells, CulturedFemaleMaleMechanotransduction, CellularModels, AnimalPhysical StimulationRatsRats, Sprague-Dawleyadenosine triphosphateastrocytescalciumiron oxide particlesmagnetic actuationmagnetomechanical stimulation

Identifiers

PMID34927381
PMCPMC8867145
OpenAlexW4200035001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.