ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
A General Method to Develop Highly Environmentally Sensitive Fluorescent Probes and AIEgens.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Manipulating excited-state dynamics through macrocycle positioning in a rotaxane for sensitive and discriminative methanol sensing.Chemical science · 2026Article
- Molecular Descriptor of Electronic Transition for Regulating Polarity-Responsive Behavior of Heterocycle-Containing Probes.JACS Au · 2026Article
- Chemical fluorophores for fluorescence lifetime imaging.Chemical Society reviews · 2026Review
- Hyperspectral Fluorescence Imaging with a New Polarity-Ultrasensitive Fluorescent Probe.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fluorescent Isostere (Journal of medicinal chemistry · 2025Article
- Interpretable Artificial Intelligence Decodes the Chemical Structural Essence of Twisted Intramolecular Charge Transfer and Planar Intramolecular Charge Transfer Fluorophores.Research (Washington, D.C.) · 2025Article
- Targeted Photoactivatable Green-Emitting BODIPY Based on Directed Photooxidation-Induced Activation and its Application to Live Dynamic Super-Resolution Microscopy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- A NIR Dual-Channel Fluorescent Probe for Fluctuations of Intracellular Polarity and HChemical & biomedical imaging · 2024Article
- Turn-on mode probe based on the sustainable xanthohumol extract for the efficient viscosity response in a liquid system.RSC advances · 2024Article
- Review
- Fluorescent Solvatochromic Probes for Long-Term Imaging of Lipid Order in Living Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Rational Design of Near-Infrared Fluorescent Probes for Accurately Tracking Lysosomal Viscosity with Allyl Snchoring Si-Rhodamine.Chemical & biomedical imaging · 2024Article
- Dual-Functional Fluorescent Probe in the Diagnosis of Liver Injury and the Evaluation of Drug Therapy with Double Signal Amplification.Chemical & biomedical imaging · 2024Article
- Computational chemistry-assisted design of hydrazine-based fluorescent molecular rotor for viscosity sensors.Smart molecules : open access · 2023Article
- Azacrown-calixpyrrole isosteres: receptors and sensors for anions.Chemical science · 2023Article
- A General Method to Develop Highly Environmentally Sensitive Fluorescent Probes and AIEgens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Environmentally sensitive fluorescent probes (including AIEgens) play pivotal roles in numerous biological studies. Many of these functional materials are developed based on the twisted intramolecular charge transfer (TICT) mechanism. However, the TICT tendency of dialkylated amino groups in biocompatible main-stream fluorophores (i.e., coumarins and rhodamines) is weak, limiting their sensitivities. Herein, by replacing dialkylated amino donors with an N-methylpyrrole group to enhance TICT, a simple and general method to engineer highly environmentally sensitive fluorescent probes is reported. This method yields a platter of colorful fluorescent probes that demonstrates outstanding polarity and viscosity sensitivity with large turn-on ratios (up to 191 times for polarity and 14 times for viscosity), as well as distinct aggregation-induced emission (AIE) characteristics. The utilities of these probes in both wash-free bioimaging and protein detections are also successfully demonstrated. It is expected that this molecular design strategy will inspire the creation of many environmentally sensitive probes.
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