ArticleExploration of medicine2021
Digital sleep measures and white matter health in the Framingham Heart Study.
Article in Exploration of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Neuroscience meets behavior: A systematic literature review on magnetic resonance imaging of the brain combined with real-world digital phenotyping.Human brain mapping · 2024Pooled it
- Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality.NEJM AI · 2026Article
- Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults.Sleep advances : a journal of the Sleep Research Society · 2026Article
- The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sleep apnea physiological burdens and markers of white matter injury: the Multi-Ethnic Study of Atherosclerosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota.Pharmaceutical biology · 2024Review
- Shifting From Active to Passive Monitoring of Alzheimer Disease: The State of the Research.Journal of the American Heart Association · 2024Review
- Obstructive Sleep Apnea - Influence on the Cardiovascular System and Cognition.Laryngo- rhino- otologie · 2023Article
- Association Between Acoustic Features and Brain Volumes: the Framingham Heart Study.Frontiers in dementia · 2023Article
- Cardiopulmonary Coupling.Advances in experimental medicine and biology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aimImpaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort.
methodsThe target population was the Framingham Heart Study Generation-2/Omni-1 Cohorts. Magnetic resonance imaging (diffusion tensor imaging) was used to assess WM integrity. Wearable digital devices were used to assess sleep quality: the (M1-SleepImage
resultsStable sleep was positively associated with WM health. Actigraphic periods of wake during the sleep period were associated with increased mean diffusivity. One marker of sleep fragmentation which covaries with respiratory chemoreflex activation was associated with reduced fractional anisotropy and increased mean diffusivity. Both oxygen desaturation index and oxygen saturation time under 90% were associated with pathological directions of diffusion tensor imaging signals. Gender differences were noted across most variables, with female sex showing the larger and significant impact.
conclusionsSleep quality assessed by a novel digital analysis and sleep hypoxia was associated with WM injury, especially in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.