ArticleBrain, behavior, & immunity - health2021
A review and novel theoretical model of how negative emotions influence inflammation: The critical role of emotion regulation.
Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A systematic review of associations between emotion regulation characteristics and inflammation.Neuroscience and biobehavioral reviews · 2023Pooled it
- Short-term Psychodynamic Psychotherapy in Addition to Standard Medical Therapy Increases Clinical Remission in Adolescents and Young Adults with Inflammatory Bowel Disease: a Randomised Controlled Trial.Journal of Crohn's & colitis · 2024Trial
- Worry and Mindfulness Differentially Impact Symptom Burden Following Treatment Among Breast Cancer Survivors: Findings From a Randomized Crossover Trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Trial
- Depression in left-behind children: a network analysis and chained mediation of attachment and emotion regulation.BMC psychology · 2026Article
- Dynamic interactions between physical activity, exercise adherence, and adverse psychological states in Chinese older adults: a cross-lagged network analysis.Frontiers in public health · 2026Article
- Psychological resources and illness recovery in later life: independent associations of positive mental health and attitudes to aging.BMC geriatrics · 2025Article
- The relationship of religiosity, spirituality and health in Spanish cancer patients: testing underlying psychological, social and behavioral pathways.BMC psychology · 2025Article
- Emotional Dysregulation, Hopelessness and Dysmorphophobic Concerns Among Hospitalized Patients with Autoimmune, Inflammatory, and Metabolic Skin Disorders.Behavioral sciences (Basel, Switzerland) · 2025Article
- Differences in Emotional Awareness Moderate Cytokine-Symptom Associations Among Breast Cancer Survivors.Brain, behavior, and immunity · 2025Article
- Gut microbiota, nutrients, and depression.Frontiers in nutrition · 2025Review
- Quality of life in hospitalized COVID-19 patients: the role of psychosocial, inflammatory, and dopaminergic pathways.Frontiers in psychology · 2025Article
- Underlying biological mechanisms of emotion dysregulation in bipolar disorder.Frontiers in psychiatry · 2025Review
- Couples in breast cancer survivorship: Daily associations in relationship satisfaction, stress, and health.Comprehensive psychoneuroendocrinology · 2024Article
- The association between religious beliefs and values with inflammation among Middle-age and older adults.Aging & mental health · 2024Article
- Moving toward affective immunology: Legacy and future directions.Comprehensive psychoneuroendocrinology · 2024Article
- Childhood Adversity and Adult Inflammation: Exploring the Mediating Role of Emotion Regulation in the MIDUS II Study.Journal of child & adolescent trauma · 2024Article
- Children's empathy moderates the association between perceived interparental conflict and child health.Brain, behavior, and immunity · 2024Article
- Emotion regulation shows an age- and sex-specific moderating effect on the relationship between chronic stress and cognitive performance.Scientific reports · 2024Article
- The Mediating Roles of Self-Compassion and Emotion Regulation in the Relationship Between Psychological Resilience and Mental Health Among College Teachers.Psychology research and behavior management · 2024Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Psychological distress is an inevitable part of life. Research drawing on theories from clinical psychology, health psychology, and psychoneuroimmunology (PNI) has identified relationships between negative emotions such as anxiety and sadness with inflammation. When not regulated properly, negative emotions can create biological wear and tear on the body that can increase risk for morbidity and mortality. This review discusses previously available research on relationships between negative emotions and emotion regulation with inflammation among both physically healthy adults and those with chronic illnesses. I then present a novel comprehensive biobehavioral model of negative emotionality. This model emphasizes the influence of negative emotions and their contribution to heightened inflammation. Further, I also discuss how emotion regulation (including perseverative processes such as worry and rumination) mediates this association. The relationships between negative emotionality and emotion regulation may be bidirectional, and empirical investigation of this model should specifically seek to disentangle these relationships. The proposed model offers the opportunity to advance PNI research through understanding how emotional factors alter inflammation and contribute to accelerated biological aging and disease risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.