ArticleHGG advances2022
Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide.
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Article in HGG advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 7 of them syntheses that pooled it.
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47citing papers in PubMed, 7 pooled it
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47 citing papers in PubMed, 7 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Integration of GWAS and single-cell analysis for psoriasis identifies disease-associated cell subtypes and therapeutic targets.Nature communications · 2026Pooled it
- Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.Briefings in bioinformatics · 2025Pooled it
- GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.Nature communications · 2025Pooled it
- Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.Journal of translational medicine · 2025Pooled it
- The causal relationship between serum metabolites and the risk of psoriasis: a Mendelian randomization and meta-analysis study.Frontiers in immunology · 2024Pooled it
- Shared Genetic Risk Factors for Multiple Sclerosis/Psoriasis Suggest Involvement of Interleukin-17 and Janus Kinase-Signal Transducers and Activators of Transcription Signaling.Annals of neurology · 2023Pooled it
- Shared genetic risk factors and causal association between psoriasis and coronary artery disease.Nature communications · 2022Pooled it
- Immune markers mediate genetic relationships between immune diseases and psychiatric disorders.PLoS genetics · 2026Article
- Integrated multi-omics strategies for identifying novel therapies in psoriasis.Bioinformatics (Oxford, England) · 2026Article
- Genome-Wide Association Study of Psoriasis, Psoriatic Arthritis, Anti-TNF-α Response, and Polygenic Risk Score in a Russian Cohort.International journal of molecular sciences · 2026Article
- Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization.BMC medicine · 2026Article
- Integrative mendelian randomization approaches for therapeutic target prioritisation in immune-mediated diseases.Scientific reports · 2026Article
- ReverseGWAS identifies combined phenotypes associated with a genotype in GWA studies.Bioinformatics (Oxford, England) · 2026Article
- Population-Based Multi-Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity.Communications medicine · 2026Article
- Psoriasis risk allele function in activated Th1/17 cells with "memory" to antigen exposure.PloS one · 2026Article
- Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.Cell genomics · 2025Article
- Article
- Causal associations between 17 common autoimmune diseases and aortic diseases: a Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Investigating the causal role of serum metabolites in substance use disorder risk: a study integrating Mendelian randomization and synthesis analysis.Discover mental health · 2025Article
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Authors and funding
23 authors at 5 institutions in 4 countries.
Philip E StuartDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Lam C TsoiDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Rajan P NairDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Manju GhoshDepartment of Pediatrics Genetics, All India Institute of Medical Sciences, New Delhi, India.
Madhulika KabraDepartment of Pediatrics Genetics, All India Institute of Medical Sciences, New Delhi, India.
Pakeeza A ShaiqDepartment of Biochemistry, PMASAA University, Rawalpindi, Pakistan.
Ghazala K RajaDepartment of Biochemistry, PMASAA University, Rawalpindi, Pakistan.
Raheel QamarCOMSATS Institute of Information Technology, Islamabad, Pakistan.
B K ThelmaDepartment of Genetics, University of Delhi South Campus, 110021 New Delhi, India.
Matthew T PatrickDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Anita PariharDepartment of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Sonam SinghDepartment of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Sujay KhandpurDepartment of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Uma KumarDepartment of Rheumatology, All India Institute of Medical Sciences, New Delhi, India.
Michael WittigInstitute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
Frauke DegenhardtInstitute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
Trilokraj TejasviDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
John J VoorheesDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Stephan WeidingerDepartment of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
Goncalo R AbecasisDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Vinod K SharmaDepartment of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
James T ElderDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USAll India Institute of Medical Sciences · INClinical Research Center Kiel · DECOMSATS University Islamabad · PKUniversity of Delhi · IN
Funding
ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSTROM, REBECCA L · 1985 to 2007
$40.8MLinkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1MGenetic and Genomic Dissection of Psoriatic ArthritisR01AR063611 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD, GLADMAN, DAFNA D · 2012 to 2023
$6.2MIdentification of Psoriatic Arthritis Genes in the MHCR01AR050511 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2004 to 2013
$4.2MCombined Analysis of Gene Expression and DNA Variation in PsoriasisR01AR054966 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2007 to 2011
$3.2MFunctional Genomics of PsoriasisR01AR065183 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2013 to 2016
$1.7MGenotyping the NPF Biobank for Psoriasis Susceptibility GenesRC1AR058315 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2009 to 2010
$993kIntegrative Biology Approach to Identify and Characterize Roles of lncRNAs Associated with Psoriasis PathologyK01AR072129 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TSOI, LAM CHEUNG · 2017 to 2021
$500kDesign Approaches for Sequencing Disease-Associated Regions in PsoriasisU01HG005924 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2010 to 2010
$221kNCRR NIH HHS M01 RR000042NHGRI NIH HHS U01 HG005924NIAMS NIH HHS K01 AR072129NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01 AR050511NIAMS NIH HHS R01 AR054966NIAMS NIH HHS R01 AR063611NIAMS NIH HHS R01 AR065183NIAMS NIH HHS RC1 AR058315
Abstract
Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genomewide association study (GWAS) of psoriasis in South Asians (SAS), consisting of 2,590 cases and 1,720 controls. Comparison with our existing European-origin (EUR) GWAS showed that effect sizes of known psoriasis signals were highly correlated in SAS and EUR (Spearman ρ = 0.78;
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genome-wide association studyhuman leukocyte antigensimputationmajor histocompatibility complex
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