Evidence map›Paper›PMID 34927046›Full record

ArticleMaterials today. Bio2022

Thermogels containing sulfated hyaluronan as novel topical therapeutics for treatment of ocular surface inflammation.

Duc Dung Nguyen, Li-Jyuan Luo, Jui-Yang Lai

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 56 citations in OpenAlex.

  1. Impact of 0.05% cyclosporine A on visual quality in patients with Post-refractive surgery dry eye.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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  7. Micelle nanogel-based drug delivery system for lutein in ocular administration.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
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  10. Photothermal-Responsive Soluble Microneedle Patches for Meibomian Gland Dysfunction Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Duc Dung NguyenGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan.
Li-Jyuan LuoGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan.
Jui-Yang LaiGraduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan.
Chang Gung University · TWMing Chi University of Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of long lasting therapeutic agents is critically important for efficient treatment of chronic diseases. We herein report a rational strategy to develop a therapeutic thermogel featured with prolonged anti-inflammatory and corneal-protective effects. Specifically, a hyaluronic acid with different sulfation degrees and an amine-terminated poly(

Indexed as

Leukocyte infiltrationOcular surface inflammationSulfated hyaluronic acidThermogelTissue protection

Identifiers

PMID34927046
PMCPMC8649391
OpenAlexW4200370166

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.