ArticleMaterials today. Bio2022
A nanosized anionic MOF with rich thiadiazole groups for controlled oral drug delivery.
Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Size dependent competitive adsorption of polystyrene micro and nanoplastics on a magnetic FeRSC advances · 2026Article
- Exploration of covalent-organic frameworks and metal-organic frameworks for drug delivery applications.Frontiers in chemistry · 2026Review
- Metal-organic frameworks in pharmaceutical research.Pharmaceutical science advances · 2025Review
- Zirconium-based MOFs as pH-responsive drug delivery systems: encapsulation and release profiles of ciprofloxacin.RSC advances · 2025Article
- Preparation and Evaluation of an Oral Administration System of Albendazole-Metal-Organic Framework Based on Dual Response to pH and Enzymes.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Application of Metal-Organic Frameworks Nanoparticles in the Diagnosis and Treatment of Breast Cancer.International journal of nanomedicine · 2025Review
- Metal-organic frameworks in oral drug delivery.Asian journal of pharmaceutical sciences · 2024Article
- Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery.Nanoscale advances · 2024Review
- Metal-organic frameworks: Drug delivery applications and future prospects.ADMET & DMPK · 2024Review
- Host-guest charge transfer for scalable single crystal epitaxy of a metal-organic framework.Communications materials · 2024Article
- Metal-Organic Framework (MOF)-A Universal Material for Biomedicine.International journal of molecular sciences · 2023Review
- Prediction of the Ibuprofen Loading Capacity of MOFs by Machine Learning.Bioengineering (Basel, Switzerland) · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlling the crystal size and surface chemistry of MOF materials, and understanding their multifunctional effect are of great significance for the biomedical applications of MOF systems. Herein, we designed and synthesized a new anionic MOF, ZJU-64-NSN, which features 1D channels decorated with highly polarized thiadiazole groups, and its crystal size could be systematically tuned from 200 μm to 300 nm through a green and simple approach. As a result, the optimal nanosized ZJU-64-NSN is found to enable an ultrafast loading of cationic drug procainamide (PA) (21.2 wt% within 1 min). Moreover, the undesirable chemical stability of PA@ZJU-64-NSN is greatly improved by the surface coating of polyethylene glycol (PEG) biopolymer. The final drug delivery system PEG/PA@ZJU-64-NSN is found to effectively prevent PA from premature release under the harsh stomach environments due to the intense host-guest interaction, and mainly release PA to the targeted intestinal surroundings. Such controlled drug delivery is proved to be triggered by endogenic Na
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.