Evidence map›Paper›PMID 34926891›Full record

ArticleACS omega2021

Ultrasonic-Assisted Synthesis of Fe-BTC-PEG Metal-Organic Complex: An Effective and Safety Nanocarrier for Anticancer Drug Delivery.

Phuong Thi Hoai Nguyen, Bac Thanh Le, Ha Duc Ninh, Duong Duc La

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Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Phuong Thi Hoai NguyenInstitute of Chemistry and Materials, Nghia Do, Cau Giay, Hanoi 100000, Vietnam.
Bac Thanh LeInstitute of Chemistry and Materials, Nghia Do, Cau Giay, Hanoi 100000, Vietnam.
Ha Duc NinhInstitute of Chemistry and Materials, Nghia Do, Cau Giay, Hanoi 100000, Vietnam.
Duong Duc LaInstitute of Chemistry and Materials, Nghia Do, Cau Giay, Hanoi 100000, Vietnam.ORCID https://orcid.org/0000-0003-4241-4431

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The porous metal-organic complexes are emerging as novel carriers for effective and safe delivery of drugs for cancer treatment, minimizing the side effect of drug overuse during cancer treatment. This study fabricated the Fe-BTC-PEG metal-organic complex from Fe ions, trimesic acid, and poly(ethylene glycol) as precursors using an ultrasonic-assisted method. The morphology and crystallinity of the resultant complex were observed by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. FTIR spectroscopy was employed to investigate the functional groups on the surface of the Fe-BTC-PEG complex. The result showed that the prepared Fe-BTC-PEG complex was in particle form with low crystallinity and diameter ranging from 100 to 200 nm. The obtained Fe-BTC-PEG complex exhibited a high loading capacity for the 5-fluorouracil (5-FU) anticancer drug with a maximal capacity of 364 mg/g. The releasing behavior of 5-fluorouracil from the 5-FU-loaded Fe-BTC-PEG complex was studied. Notably, the acute oral toxicity of the Fe-BTC-PEG metal-organic complex was also carried out to evaluate the safety of the material in practical application.

Identifiers

PMID34926891
PMCPMC8674903

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.